Cyclic oligoadenylates such as c-tetraAMP were found to be novel bacterial second messengers involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements in many prokaryotes. References: Kazlauskiene et al., Science, 357, 605 - 609 (2017); Niewoehner et al., Nature, 548, 543 - 548 (2017).
"Future Products" list structures which are nearly ready for commercialisation. The list will be permanently updated and contains already > 80 items at the moment.
pppG(2',5')pA is considered to be the linear catalytic intermediate in the enzymatic production of 2',3' - cGAMP (aka c[G(2',5')pA(3',5')p], BIOLOG Cat. No. C 161) by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). According to Hall e t al. (2017) human stimulator of interferon genes STING 155 - 341 does not bind pppG(2',5')pA at concentrations of up to 50 μM.
In pppApG a 5'-ATP unit is connected with a 5'-GMP unit via a 3' → 5' linkage to form a linear dinucleotide. pppApG is a potential endogenous metabolite of the metazoan second messenger 2',3'-cGAMP (c[G(2',5')pA(3',5')p], Cat. No. C 161) and/or of the bacterial signalling nucleotide 3'3'-cGAMP (c-(ApGp), Cat. No. C 117). Kranzusch et al. (2014) reported pppApG to be the linear dinucleotide intermediate in the enzymatic production of 3',3'-cGAMP by the Vibrio cholerae pathogenicity factor DncV. References: Kranzusch, P.J. et al., Cell, 158, 1011 - 1021 (2014); Deng, T. et al., J. Virol., 80, 2337 - 2348 (2006).
With Rp-2'-F-dATP-α-S (Cat. No. D 220) and Sp-2'-F-dATP-a-S (Cat. No. D 219) the sulfur-modified analogues of 2'-deoxy-2'-fluoro-ATP (Cat. No. D 074), which are considered to be metabolically more stable, have been added to our product list. In addition, c[3'-[sCya7]-AHC-G(2',5')pA(3',5')p], (Cat. No. C 240), a new NIR fluorescent 2',3'-cGAMP analogue has joined the cyclic dinucleotide tools set.
8-Br-2',3'-cAMP (Cat. No. B 280) is now available from Biolog. This compound is considered to be a membane-permeable analogue of 2',3'-cAMP (Cat. No. A 307) and was recently used by Kosmacz et al. (2018) to study the role of 2',3'-cAMP in the formation of stress granules in Arabidopsis thaliana (Reference: Kosmacz et al., Plant Physiol., 177, 411 - 421 (2018): "Interaction of 2',3'-cAMP with Rbp47b Plays a Role in Stress Granule Formation").
Biolog now offers the endogenous Transient Receptor Potential Melastatin 2 (TRPM2) channel superagonist and potential novel second messenger 2'-deoxy-ADPR (Reference: Fliegert et al., Nat. Chem. Biol., 13, 1036 - 1044 (2017): "2'-Deoxyadenosine 5'-diphosphoribose is an Endogenous TRPM2 Superagonist").
We have added three new products to our product line of NAD and ADPR analogues:
Our product DEACM-caged cAMP (Cat. No. D 042) which was temporarily out of stock, is available again. DEACM-caged cAMP is a caged precursor of the second messenger cAMP and releases both cAMP and a fluorescent coumarin analogue upon irradiation.
Biolog is pleased to be one of the sponsors of the upcoming 70th Annual Meeting of the German Society for Hygiene and Microbiology e. V. (DGHM, February 19-21, 2018, Bochum, Germany, www.dghm-kongress.de) and of the 3rd German Pharm-Tox Summit (DGPT, February 26-March 1, 2018, Göttingen, Germany, www.gpts-kongress.de).
Biolog's Quality Management System certification has been upgraded to the new ISO 9001:2015 standard. Please click here to download a PDF of our updated certificate.
The newly discovered bacterial second messenger c-hexaAMP (syn.: cyclic hexaadenylate / c-A6 / cA6) is now available from Biolog.
c-hexaAMP was recently reported by Niewoehner et al. (2017) and Kazlauskiene et al. (2017) to be a signalling molecule in prokaryotes, involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements.
We have added a number of new NAD+ analogues, mostly modified at the 8-position of the adenine ring, to our product catalogue. Many of these structures are described in a collaborative paper recently published in Science: Gibson et al., Science, 353, 45 - 50 (2016): "Chemical Genetic Discovery of PARP Targets Reveals a Role for PARP-1 in Transcription Elongation".
Biolog is one of the sponsors of the upcoming 8th International Conference on cGMP - cGMP: Generators, Effectors and Therapeutic Implications. The conference will take place June 23-25, 2017 in Bamberg, Germany.
Visit the meeting website at www.cyclicgmp.net for further information on this event.
Biolog sponsors Microbiology and Infection 2017, the 5th Joint Conference of the DGHM (German Society for Hygiene and Microbiology) & VAAM (Association for General and Applied Microbiology), which will be held March 5-8, 2017 in Würzburg, Germany.
Visit the meeting website at www.microbiology-infection.de for further information on this event.
Latest additions to our product line of cyclic dinucleotides are:
We have added three new products to our broad product line of cyclic nucleotides:
Biolog sponsors the 20th Joint Meeting of the Signal Transduction Society (STS) "Signal Transduction – Receptors, Mediators and Genes" which will be held November 9-11, 2016 in Weimar/Germany. Visit the homepage of the Signal Transduction Society at https://sigtrans.de/index.html.
Three new linear dinucleotides have become available from Biolog:
Biolog sponsors the 5th International Meeting on Anchored cAMP Signaling Pathways which will be held October 6-9, 2016 in Zermatt, Switzerland.
Visit the meeting website at https://wp.unil.ch/akap2016/ for further information on this important event.
We are happy to introduce the new www.biolog.de to you. Our website has been completely revised to offer a fresh look, an extended search function for our products, and an improved online shop system.
If you are a registered user of www.biolog.de, please note that for the purpose of data protection, your address details and login information have not been transferred to the new website. We would therefore like to ask you to create a new online account.
Biolog sponsors the upcoming 22nd International Round Table on Nucleosides, Nucleotides and Nucleic Acids (XXII IRT) (Paris/France, July 18 - 22, 2016, www.paris-irt2016.org).
Biolog sponsors the upcoming German Pharm-Tox Summit 2016 (DGPT) (Berlin/Germany, February 29 - March 3, 2016) and the Annual Conference of the Association for General and Applied Microbiology (VAAM) (Jena/Germany, March 13 - 16, 2016).
The cyclic dinucleotide 2'2'-cGAMP (c[A(2',5')pG(2',5')p], Cat. No. C 210) is now available from Biolog.
Similar to the metazoan second messenger 2'3'-cGAMP (Cat. No. C 161), 2'2'-cGAMP binds the signalling protein STING and subsequently induces type I interferons.
Latest additions to our product line of c-diAMP and c-diGMP-related cyclic dinucleotides:
We have updated the citation lists for our products 2'3'-cGAMP (Cat. No. C 161) and biotinylated 2'3'-cGAMP (Cat. No. C 176) with a study recently published in Science:
Bridgeman, A.; Maelfait, J.; Davenne, T.; Partridge, T.; Peng, Y.; Mayer, A.; Dong, T.; Kaever, V.; Borrow, P.; Rehwinkel, J., Science, 349, 1228 - 1232 (2015): "Viruses Transfer the Antiviral Second Messenger cGAMP Between Cells" - Link to PubMed
Biolog now offers a set containing 0.1 µmol each of c[G(2',5')pS-A(3',5')pS], isomer 1 and c[G(2',5')pS-A(3',5')pS], isomer 2 which are isomeric di-thiophosphate analogues of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka 2'3'-cGAMP, Cat. No. C 161). Please visit the product detail page for further information on the set.
We are pleased to announce a significant price reduction for our products pApA (Cat. No. P 033) and pGpG (Cat. No. P 023). These products are now sold in 1 µmol vials instead of 0.1 µmol vials at unchanged prices. Please visit the product detail pages for pApA and pGpG for further information.
Together with academic collaborators, Biolog has developed new EPAC agonists that discriminate between the isoforms EPAC1 and EPAC2. Two of the cyclic AMP-based structures described are now exclusively available from Biolog:
Reference: Schwede, F. et al., PLoS Biol., 13(1):e1002038 (2015): "Structure-Guided Design of Selective Epac1 and Epac2 Agonists" (Link to PLoS Biology)