For other salt forms please inquire. Polymer-linked dimeric (PLD) cGMP analogue in which two cGMP units are linked by a spacer with 8 ethylene oxide units via thioethers at the C8 positions. In addition, β-phenyl-1,N2-etheno (PET) groups have been attached to both guanine nucleobases.
Membrane-permeant cGMP dimer with enhanced PKG activation properties by addressing two binding sites simultaneously with a single molecule.
Activation constants of PET-cGMP-8-TMAmd-(EO)8-EAmdMT-8-cGMP-PET in vitro on purified cGMP-dependent protein kinase (PKG) isozymes were measured to be in the range of < 1 nM (PKG1α and PKG1β) and ~35 nM (PKG2), respectively (BIOLOG in-house data).
Cat. No. | P 054 |
CAS number | [2201858-61-7] |
Purity | > 98% HPLC |
Salt form | Disodium |
Storage temperature | -20°C / -4°F |
Molecular formula | C₅₈H₇₀N₁₂O₂₄P₂S₂ · Na₂ |
Molecular weight [g/mol] | 1491.3 |
Modifications | 1-cGMP, 2-cGMP, 8-cGMP |
Target | PKG (cGK) Activator |
Absorption max [nm] | 271 |
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 72000 |
UV pH value | 7 |