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PET-cGMP-8-TMAmd-(EO)₈-EAmdMT-8-cGMP-PET

β- Phenyl- 1, N²- ethenoguanosine- 3', 5'-cyclic monophosphate- [8- thiomethylamido- (octaethoxy)- ethylamidomethylthio- 8]- β- phenyl- 1, N²- ethenoguanosine- 3', 5'-cyclic monophosphate ( PET-cGMP-8-TMAmd-(EO)₈-EAmdMT-8-cGMP-PET ), sodium salt

Polymer-linked dimeric (PLD) cGMP analogue
Cat. No.: P 054
    
CAS No.: [2201858-61-7]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: P 054-01
Unit: 1 µmol / ~1.5 mg
$291.00

For other salt forms please inquire. Polymer-linked dimeric (PLD) cGMP analogue in which two cGMP units are linked by a spacer with 8 ethylene oxide units via thioethers at the C8 positions. In addition, β-phenyl-1,N2-etheno (PET) groups have been attached to both guanine nucleobases.
Membrane-permeant cGMP dimer with enhanced PKG activation properties by addressing two binding sites simultaneously with a single molecule.
Activation constants of PET-cGMP-8-TMAmd-(EO)8-EAmdMT-8-cGMP-PET in vitro on purified cGMP-dependent protein kinase (PKG) isozymes were measured to be in the range of < 1 nM (PKG1α and PKG1β) and ~35 nM (PKG2), respectively (BIOLOG in-house data).

Cat. No. P 054
CAS number [2201858-61-7]
Purity > 98% HPLC
Salt form Disodium
Storage temperature -20°C / -4°F
Molecular formula C₅₈H₇₀N₁₂O₂₄P₂S₂ · Na₂
Molecular weight [g/mol] 1491.3
Modifications 1-cGMP, 2-cGMP, 8-cGMP
Target PKG (cGK) Activator
Absorption max [nm] 271
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 72000
UV pH value 7