For other salt forms please inquire. Polymer-linked dimeric (PLD) cGMP analogue in which two cGMP units are linked by a spacer with 8 ethylene oxide units via thioethers at the C8 positions. In addition, β-phenyl-1,N2-etheno (PET) groups have been attached to both guanine nucleobases.
Membrane-permeant cGMP dimer with enhanced PKG activation properties by addressing two binding sites simultaneously with a single molecule.
Activation constants of PET-cGMP-8-TMAmd-(EO)8-EAmdMT-8-cGMP-PET in vitro on purified cGMP-dependent protein kinase (PKG) isozymes were measured to be in the range of < 1 nM (PKG1α and PKG1β) and ~35 nM (PKG2), respectively (BIOLOG in-house data).
|Cat. No.||P 054|
|Purity||> 98% HPLC|
|Storage temperature||-20°C / -4°F|
|Molecular formula||C₅₈H₇₀N₁₂O₂₄P₂S₂ · Na₂|
|Molecular weight [g/mol]||1491.3|
|Modifications||1-cGMP, 2-cGMP, 8-cGMP|
|Target||PKG (cGK) Activator|
|Absorption max [nm]||271|
|Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]||72000|
|UV pH value||7|