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Guanosine- 2', 3'- cyclic monophosphorothioate, endo / Rp- isomer ( Rp-2',3'-cGMPS ), sodium salt

Cat. No.: G 070
CAS No.: [38557-85-6]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: G 070-05
Unit: 5 µmol / ~1.9 mg

For other salt forms please inquire. Rp-2',3'-cGMPS and its corresponding Sp-isomer (Sp-2',3'-cGMPS, Cat. No. G 071) are valuable tools for determination of the stereochemical requirements of 2',3'-cGMP binding receptors. Depending on the type of receptor they could behave as agonists or inhibitors of the binding site. Often phosphorothioate-modified nucleotides are more stable against metabolic degradation compared to their sulfur-free parent structures. 

According to Eckstein et al. (1972), Rp-2',3'-cGMPS is hydrolyzed by ribonuclease T1 (RNase T1), which  converts guanosine 3'-phosphate esters to guanosine 3'-phosphate with guanine 2′,3′-cyclic monophosphate (2′,3′-cGMP) as intermediate, while the Sp-isomer Sp-2',3'-cGMPS resists hydrolysis and acts as a competitive inhibitor for this enzyme. Reference: Eckstein et al., Biochemistry, 11, 3507 - 3512 (1972)

Cat. No. G 070
CAS number [38557-85-6]
Purity > 97% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₁N₅O₆PS · Na
Molecular weight [g/mol] 383.3
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300
UV pH value 7
Solvent for UV data Water