BIOLOG is an innovative and scientifically orientated enterprise based in Germany, which is specialized in tools for signal transduction research.
The ISO 9001-certified company has its focus on nucleotide chemistry with special emphasis on cyclic nucleotide-based modulators of respective protein kinases, phosphodiesterases and ion channels, etc.
Numerous rare cyclic AMP and GMP agonists and antagonists of high purity have been developed which differ in terms of membrane permeability, receptor specificity and kinase isozyme selectivity or which carry fluorescent labels.
For affinity chromatography of cyclic nucleotide-binding proteins, gels with PDE-stable ligand structures are available as well.
Custom syntheses and custom purifications, especially in the field of mono-, di- and triphosphates as well as fluorescence labelling are other main activities of the company.
At BIOLOG there is permanent research on novel specific modulators of cyclic nucleotide-responsive receptors which has already led to several generally accepted tools for signal transduction research, such as PKA and PKG inhibitors as well as Epac-specific agonists.
The company collaborates scientifically with other research groups as well, mainly on receptor mapping studies and the development of novel enzyme modulators by means of nucleotide analogues (click here for a list of literature references).
Since most of the products offered are synthesised in own laboratories there is a strong background in nucleotide chemistry and corresponding scientific areas.