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c[G(2',5')pG(3',5')p] / 2'3'-c-diGMP

Cyclic (guanosine- (2' −> 5')- monophosphate- guanosine- (3' −> 5')- monophosphate) ( c[G(2',5')pG(3',5')p] / 2'3'-c-diGMP / 2',5'-3',5'-c-diGMP ), sodium salt
Cat. No.: C 182
CAS No.: [1638241-12-9]
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Product Name Price (net) Qty
Cat. No.: C 182-005
Unit: 0.5 µmol / ~345 µg

For other salt forms please inquire. c[G(2',5')pG(3',5')p] is a cyclic dinucleotide structurally related to the bacterial second messenger c-diGMP (Cat. No. C 057). In contrast to 3',5'-linked c-diGMP, c[G(2',5')pG(3',5')p] contains two distinct phosphodiester linkages. Cai et al. (2023) discovered c[G(2',5')pG(3',5')p] to be produced in response to viral infection and to be a more potent STING agonist than 2'3'-cGAMP (Cat. No. C 161) in Drosophila melanogaster. It also activated a strong antiviral transcriptional response in Drosophila serrata. Detailed technical information available. Reference: Cai et al., Immunity56, 1991 - 2005 (2023).

Cat. No. C 182
CAS number [1638241-12-9]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₄P₂ (free acid)
Molecular weight [g/mol] 690.4 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23700