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pppApG

5'- Triphosphoadenylyl- (3' −> 5')- guanosine ( pppApG )
Potential endogenous metabolite of the metazoan second messenger 2',3'-cGAMP and/or of the bacterial signalling nucleotide 3'3'-cGAMP
Cat. No.: T 050
    
CAS No.: [68892-47-7]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: T 050-01
Unit: 1 µmol / ~0.85 mg
$203.00

For other salt forms or a guaranteed higher purity please inquire. In pppApG a 5'-ATP unit is connected with a 5'-GMP unit via a 3' → 5' linkage to form a linear dinucleotide. pppApG is a potential endogenous metabolite of the metazoan second messenger 2',3'-cGAMP (c[G(2',5')pA(3',5')p], Cat. No. C 161) and/or of the bacterial signalling nucleotide 3'3'-cGAMP (c-(ApGp), Cat. No. C 117). Kranzusch et al. (2014) reported pppApG to be the linear dinucleotide intermediate in the enzymatic production of 3',3'-cGAMP by the Vibrio cholerae pathogenicity factor DncV. References: Kranzusch, P.J. et al., Cell, 158, 1011 - 1021 (2014); Deng, T. et al., J. Virol., 80, 2337 - 2348 (2006).

 

Cat. No. T 050
CAS number [68892-47-7]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution
Storage temperature -70°C / -94°F
Molecular formula C₂₀H₂₈N₁₀O₂₀P₄ (free acid)
Molecular weight [g/mol] 852.39 (free acid)
Absorption max [nm] 256
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 25050
UV pH value 7
Solvent for UV data Water