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pppG(2',5')pA

5'- Triphosphoguanylyl- (2' −> 5')- adenosine ( pppG(2',5')pA )
Linear catalytic intermediate in the enzymatic production of 2',3'-cGAMP
Cat. No.: T 051
    
CAS No.: [1445905-50-9]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: T 051-01
Unit: 1 µmol
$203.00

For other salt forms or a guaranteed higher purity please inquire. In pppG(2',5')pA a 5'-GTP unit is connected with a 5'-AMP unit via a 2' → 5' linkage to form a linear dinucleotide. pppG(2',5')pA is considered to be the linear catalytic intermediate in the enzymatic production of 2',3'-cGAMP (aka c[G(2',5')pA(3',5')p], BIOLOG Cat. No. C 161) by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). According to Hall et al. the human stimulator of interferon genes STING155-341 does not bind pppG(2',5')pA at concentrations of up to 50 µM. Reference: Hall et al., Protein Sci., 26, 2367 - 2380 (2017).

 

Vial containing 100 µl of 10 mM aqueous solution of pH 7.6

Cat. No. T 051
CAS number [1445905-50-9]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution
Storage temperature -70°C / -94°F
Molecular formula C₂₀H₂₈N₁₀O₂₀P₄
Molecular weight [g/mol] 852.4
Absorption max [nm] 256
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 25050
UV pH value 7
Solvent for UV data Water