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Br-ANT-GTP

2'- / 3'- O- (5- Bromoanthraniloyl)guanosine- 5'- O- triphosphate ( Br-ANT-GTP ), sodium salt

Fluorescent GTP analogue
Cat. No.: B 152
    
CAS No.: [pending]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: B 152-01
Unit: 1 µmol / ~0.7 mg
$145.00

For other salt forms or a guaranteed higher purity please inquire. Analogue of guanosine-5'-triphosphate with only moderate intrinsic fluorescence (λexc 346 nm, λem ~426 nm). The fluorophore has a certain sensitivity for its environment and is supposed to change its spectral properties upon binding. Useful for research into GTP-dependent receptor proteins. Potential inhibitor of various adenylyl cyclase isoforms and soluble guanylyl cyclase (sGC). References for related GTP analogues and nucleoside triphosphate analogues: Dove et al., Mol. Pharmacol.85, 598 - 607 (2014), Pinto et al., Biochem. Phamacol., 82, 358 - 370 (2011), Geduhn et al., J. Pharmacol. Exp. Ther., 336, 104 - 115 (2011), Gille et al., J. Biol. Chem., 279, 19955 - 19969 (2004)

 

Vial containing 100 µl of 10 mM aqueous solution of pH 7.6.

Cat. No. B 152
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution
Storage temperature -70°C / -94°F
Light-sensitive Yes
Molecular formula C₁₇H₂₀BrN₆O₁₅P₃
Molecular weight [g/mol] 721.2
Excitation max [nm] 346
Emission max [nm] 426
Absorption max [nm] 345
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 4800
UV pH value 7
Solvent for UV data Water