c[A(2',5')pG(3',5')p] is a cyclic dinucleotide structurally related to the metazoan second messenger and STING activator c[G(2',5')pA(3',5')p] (2'3'-cGAMP, Cat. No. C 161). c[A(2',5')pG(3',5')p] was found to be biosynthesized by the Drosophila melanogaster enzyme cGLR1 in response to dsRNA (Slavik et al. 2021). References: Slavik et al., Nature, 597, 109 - 113 (2021); Holleufer et al., Nature, 597, 114 - 118 (2021).
Review written by Kailey Slavik and Philip Kranzusch - Harvard Medical School, Dana-Farber Cancer Institute (download PDF).
| Cat. No. | C 238 |
| CAS number | [1615704-64-7] |
| Purity | > 98% HPLC |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₂₀H₂₄N₁₀O₁₃P₂ (free acid) |
| Molecular weight [g/mol] | 674.4 (free acid) |
| Absorption max [nm] | 256 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 25050 |
