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7- (3- (2- Azidoacetyl)aminopropargyl)- 7- deaza- 2'- deoxyguanosine- 5'- O- triphosphate ( 7-N₃Ac-AParg-7-C-dGTP ), sodium salt

Azide-containing analogue of dGTP
Cat. No.: A 392
CAS No.: [pending]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: A 392-0025
Unit: 0.25 µmol / ~161 µg

For other salt forms please inquire. The azide-containing 7-N₃Ac-AParg-7-C-dGTP is an analogue of dGTP and a suitable molecular tool for the copper(I)-catalysed Huisgen azide-alkyne [3+2] cycloaddition (CuAAC) or copper(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC) with strained alkynes, respectively. Both reactions have attracted particular interest for the introduction of reporter groups and for the labelling of various biomolecules like dGTP-binding proteins by the so-called click-chemistry technique. Azide-functionalised 7-deaza purine nucleotides can replace their natural counterpart dGTP in polymerase reactions, resulting in functionalized DNA that can subsequently be further reacted and modified using click chemistry methods. References for CuAAC and SPAAC click chemistry: Dommerholt et al., Top. Curr. Chem.374:16 (2016); Presolski et al., Curr. Protoc. Chem. Biol.3, 153 - 162 (2011); Hong et al., Angew. Chem. Int. Ed. Engl.48, 9879 - 9883 (2009)


Vial containing 250 µl of 1 mM aqueous solution of pH 7.6

Cat. No. A 392
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Appearance 1 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Light-sensitive Yes
Molecular formula C₁₆H₂₁N₈O₁₄P₃ (free acid)
Molecular weight [g/mol] 642.3 (free acid)
Absorption max [nm] 272
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 11900
UV pH value 7
Solvent for UV data Water