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Carba- β- nicotinamide adenine dinucleotide ( carba-NAD⁺ ), sodium salt

Cat. No.: C 403
CAS No.: [112345-60-5]
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Cat. No.: C 403-01
Unit: 1 µmol / ~0.7 mg

carba-NAD⁺ is a NAD⁺ mimic with improved hydrolytic stability against adenosine diphosphate ribosyl transferase (ART) enzymes and NAD glycohydrolases. carba-NAD⁺ was shown to inhibit activity of the cholera toxin A ART enzyme and NAD⁺-consuming enzymes Sirt3/5, but was ineffective against PARP1 and NAD⁺-glycohydrolase. carba-NAD⁺ is a substrate of NAD⁺-handling enzymes like alcohol dehydrogenases and is suitable as hydrolysis-resistant NAD⁺-mimic for protein crystallizations. Robust cofactor for enzyme-based glucose sensing with glucose dehydrogenases and fluorescence lifetime detection. References: Madern et al., Chembiochem.21, 2903 - 2907 (2020); von Ketteler et al. Chemphyschem., 13, 1302 - 1306 (2012), Szczepankiewicz et al. J. Org. Chem.77, 7319 - 7329 (2012).

Cat. No. C 403
CAS number [112345-60-5]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₂H₂₉N₇O₁₃P₂
Molecular weight [g/mol] 661.5 (for free acid)
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 18000
UV pH value 7