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2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP

2'- , 2''-, 2''', 2'''', 2''''', 2''''''- Hexadeoxy- 2'-, 2'', 2''', 2'''', 2''''', 2''''''- hexafluoro- cyclic hexaadenosine monophosphate ( 2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP / cFA6 ), sodium salt

Analogue of the bacterial second messenger c-hexaAMP with increased metabolic stability
Cat. No.: H 038
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: H 038-001
Unit: 0.1 µmol / ~0.2 mg
$336.00

For other salt forms please inquire. 2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP is an analogue of the bacterial second messenger c-hexaAMP (Cat. No.: C 332) containing fluoro modifications in all ribose 2'-positions. 2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP was found to be resistant to degradation by the type III CRISPR-associated ribonuclease Csm6 from Enterococcus italicus (EiCsm6) while it still activated EiCsm6 (EC50 = 170 nM), albeit more weakly than c-hexaAMP (all data according to Garcia-Doval et al., Nat Commun., 11(1):1596 (2020)).

Cat. No. H 038
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₆₀H₆₆F₆N₃₀O₃₀P₆ (free acid)
Molecular weight [g/mol] 1987.2 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 81000
UV pH value 7