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The nitrated derivative of cGMP, 8-NO2-cGMP (8-Nitro-cGMP), is considered to play an important role in NO-mediated signal transduction. Formation of protein Cys-cGMP adducts by 8-NO2-cGMP was identified as a new post-translational modification of proteins, which is called S-guanylation. Reference: Sawa et al., Nat. Chem. Biol., 3, 727 - 735 (2007).
Cat. No.
N 011
CAS number
[913645-39-3]
Storage temperature
-20°C / -4°F
Light-sensitive
True
Molecular formula
C₁₀H₁₀N₆O₉P · Na
Molecular weight [g/mol]
412.2
Modifications
8-cGMP
Target
PKG (cGK) Activator
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8. Zaki M. H., Fujii S., Okamoto T., Islam S., Khan S., Ahmed K. A., Sawa T.Akaike T., J. Immunol., 182, 3746 - 3756 (2009), "Cytoprotective Function of Heme Oxygenase 1 Induced by a Nitrated Cyclic Nucleotide Formed During murine Salmonellosis"
9. Sawa T., Zaki M. H., Okamoto T., Akuta T., Tokutomi Y., Kim-Mitsuyama S., Ihara H., Kobayashi A., Yamamoto M., Fujii S., Arimoto H.Akaike T., Nature Chem. Biol., 3, 727 - 735 (2007), "Protein S-guanylation by the Biological Signal 8-nitroguanosine 3',5'-cyclic Monophosphate"