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8- Nitroguanosine- 3', 5'- cyclic monophosphate
Second messenger of NO

Available for joint scientific collaboration projects only.
Cat. No.: N 011
CAS No.: [913645-39-3]
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The nitrated derivative of cGMP, 8-NO2-cGMP (8-Nitro-cGMP), is considered to play an important role in NO-mediated signal transduction. Formation of protein Cys-cGMP adducts by 8-NO2-cGMP was identified as a new post-translational modification of proteins, which is called S-guanylation. Reference: Sawa et al., Nat. Chem. Biol., 3, 727 - 735 (2007).
Cat. No. N 011
CAS number [913645-39-3]
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₀H₁₀N₆O₉P · Na
Molecular weight [g/mol] 412.2
Modifications 8-cGMP
Target PKG (cGK) Activator
  • 1. Ihara H., Ahtesham A. K., Ida T., Kasamatsu S., Kunieda K., Okamoto T., Sawa T.Akaike T., Nitric Oxide, 25, 169 - 175 (2011), "Methodological Proof of Immunochemistry for Specific Identification of 8-nitoguanosine 3',5'-cyclic Monophosphate Formed on Glia Cells"
  • 2. Ahtesham A. K., Sawa T.Akaike T., Amino Acids, 41, 123 - 130 (2011), "Protein Cysteine S-guanylation and Electrophilic Signal Transduction by Endogenous Nitro-nucleotides"
  • 3. Tokutomi Y., Kataoka K., Yamamoto E., Nakamura T., Fukuda M., Nako H., Toyama K., Dong Y.-F., Ahmed K. A., Sawa T., Akaike T.Kim-Mitsuyama S., Brit. J. Pharmacol., 162, 1884 - 1893 (2011), "Vascular Responses to 8-nitro-cyclic GMP in Non-diabetic and Diabetic Mice"
  • 4. Kurauchi Y., Hisatsune A., Isohama Y., Sawa T., Akaike T., Shudo K.Katsuki H., J. Neurochem., 116, 323 - 333 (2011), "Midbrain Dopaminergic Neurons Utilize Nitric Oxide/cyclic GMP Signaling to Recruit ERK that Links Retinoic Acid Receptor Stimulation to Up-regulation of BDNF"
  • 5. Okamoto T., Khan S., Oyama K., Fujii S., Sawa T.Akaike T., J. Clin. Biochem. Nutr., 46, 14 - 19 (2010), "A New Paradigm for Antimicrobial Host Defense Mediated by a Nitrated Cyclic Nucleotide"
  • 6. Fujii S., Sawa T., Ihara H., Tong K. I., Ida T., Okamoto T., Ahtesham A. K., Ishima Y., Motohashi H., Yamamoto M.Akaike T., J.Biol.Chem., 285, 23970 - 23984 (2010), "The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated cyclic GMP, in the Antioxidant Adaptive Response"
  • 7. Akaike T., Fujii S., Sawa T.Ihara H., Nitric Oxide, 23, 166 - 174 (2010), "Cell Signaling Mediated by Nitrated Cyclic Guanine Nucleotide"
  • 8. Zaki M. H., Fujii S., Okamoto T., Islam S., Khan S., Ahmed K. A., Sawa T.Akaike T., J. Immunol., 182, 3746 - 3756 (2009), "Cytoprotective Function of Heme Oxygenase 1 Induced by a Nitrated Cyclic Nucleotide Formed During murine Salmonellosis"
  • 9. Sawa T., Zaki M. H., Okamoto T., Akuta T., Tokutomi Y., Kim-Mitsuyama S., Ihara H., Kobayashi A., Yamamoto M., Fujii S., Arimoto H.Akaike T., Nature Chem. Biol., 3, 727 - 735 (2007), "Protein S-guanylation by the Biological Signal 8-nitroguanosine 3',5'-cyclic Monophosphate"