For other salt forms please inquire. Polymer-linked dimeric (PLD) cGMP analogue in which two cGMP units are linked by a spacer with 5 ethylene oxide units via thioethers at the C8 positions. Membrane-permeant cGMP dimer with enhanced PKG activation properties by addressing two binding sites simultaneously with a single molecule.
Activation constants of cGMP-8-T-(EO)₅-ET-8-cGMP in vitro on purified cGMP-dependent protein kinase (PKG) isozymes were measured to be in the range of < 1 nM (PKG1β and PKG2) and < 0.8 nM (PKG1α), respectively. The compound significantly reduced proliferation and migration combined with increased cell death in two melanoma cell lines (all data according to Vighi et al. 2017). In the colon cancer cell line HT-29, treatment with cGMP-8-T-(EO)₅-ET-8-cGMP led to a significant reduction of cell viability (Hoffmann et al. 2017). References: Vighi et al., Oncotarget, 9, 5301-5320 (2017); Hoffmann et al., Eur. J. Med. Chem., 141, 61-72 (2017).
|Cat. No.||G 031|
|Purity||> 98% HPLC|
|Storage temperature||-20°C / -4°F|
|Molecular formula||C₃₂H₄₄N₁₀O₁₉P₂S₂ · Na₂|
|Molecular weight [g/mol]||1044.8|
|Target||PKG (cGK) Activator|
|Absorption max [nm]||274|
|Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]||24660|
|UV pH value||7|