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2'- (5''- Phosphoribosyl)- adenosine- 5'- O- monophosphate ( 2'-pRib-AMP / 2'-pRib-5'-AMP / iso-ADPR ), sodium salt

Cat. No.: P 128
CAS No.: [1672716-76-5]
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Product Name Price (net) Qty
Cat. No.: P 128-005
Unit: 0.5 µmol / ~280 µg

For other salt forms please inquire. 2'-pRib-AMP is the monomeric metabolite of poly(ADP-ribose) (PAR) and can be used to detect and analyse PAR-specific binding properties of poly(ADP-ribose) polymerases (Wang et al. 2018). Recent studies have shown that plant nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain recognise pathogen effectors. The TIR-enabled nicotinamideadenine dinucleotide hydrolase (NADase) activity is used to mediate the immune response. It has been shown that TIR-containing proteins can biocatalyse the production of 2'-pRib-AMP from NAD+ in plants, and it has been postulated that 2'-pRib-AMP may have a second messenger function in TIR signalling of plant immunity (Jia et al. 2022, Huang et al. 2022). References: Wang et al., Methods Mol. Biol.1813, 65 - 73 (2018); Jia et al., Science, 377:eabq8180 (2022); Huang et al., Science, 377:eabq3297 (2022)


Cat. No. P 128
CAS number [1672716-76-5]
Purity > 95% HPLC
Salt form Sodium
Appearance Solid
Storage temperature -20°C / -4°F
Molecular formula C₁₅H₂₃N₅O₁₄P₂ (free acid)
Molecular weight [g/mol] 559.3 (free acid)
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
UV pH value 7
Solvent for UV data Water