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Cyclic triadenosine monophosphate ( c-triAMP / c-tri-AMP / cyclic triadenylate / c-A3 / cA3 / cOA3 ), sodium salt

Cyclic oligoadenylate involved in Type III CRISPR-Cas systems in prokaryotes
Cat. No.: C 362
CAS No.: [54447-85-7]
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Cat. No.: C 362-005
Unit: 0.5 µmol / ~0.5 mg

For other salt forms please inquire. c-triAMP is a cyclic oligoadenylate involved in Type III CRISPR-Cas systems in prokaryotes. Upon recognition and binding of invasive target RNA, the Cas10 subunit of the type III interference complex generates cyclic oligoadenylates which in turn act as allosteric activators of Csm6 ribonucleases that degrade invader-derived RNA transcripts. c-triAMP was found to be the predominant reaction product in Streptococcus thermophilus while only c-hexaAMP activates the Csm6 ribonuclease of this organism (Kazlauskiene et al. (2017)). Reference: Kazlauskiene et al., Science, 357, 605 - 609 (2017).

Cat. No. C 362
CAS number [54447-85-7]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₃₀H₃₆N₁₅O₁₈P₃ (free acid)
Molecular weight [g/mol] 987.6 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 40500
UV pH value 7