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β- Benzamide adenine dinucleotide ( BAD ), sodium salt

Analogue of β-NAD⁺ with improved stability
Cat. No.: B 301
CAS No.: [156724-91-3]
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Cat. No.: B 301-01
Unit: 1 µmol / ~0.7 mg

BAD is the biologically active metabolite of benzamide riboside and a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH). It was also found to be a potent and competitive inhibitor of human NAD kinase (Ki = 90 µM) and, at higher concentration and to a lower extent, of the bacterial enzyme (Bonnac et al. 2007). Furthermore, BAD is a non-hydrolysable substrate/inhibitor of NADases and PARP enzymes. BAD was used in co-crystallization experiments with NADases (Strømland et al. 2021) and PARP1 (Langelier et al. 2018). References: Bonnac et al., Bioorg. Med. Chem. Lett., 17, 1512 - 1515 (2007); Langelier et al., Nat. Commun., 9(1):844 (2018); Strømland et al., Nat. Commun., 12(1):1631 (2021).

Cat. No. B 301
CAS number [156724-91-3]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₂H₂₈N₆O₁₄P₂ (free acid)
Molecular weight [g/mol] 662.4 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
UV pH value 7