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N-2'-dAD⁺ / 2'-deoxy-NAD⁺

β- Nicotinamide- 2'- deoxyadenine dinucleotide ( N-2'-dAD+ / 2'-deoxy-NAD+ ), sodium salt

Potential precursor of the endogenous TRPM2 superagonist dADPR
Cat. No.: N 065
CAS No.: [1514900-83-4]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: N 065-01
Unit: 1 µmol / ~0.6 mg

For other salt forms please inquire. N-2'-dAD⁺ is a 2'-deoxyadenosine version of the coenzyme nicotinamide adenine dinucleotide (β-NAD+). It is considered to be a substrate for type III CD38 in the enzymatic production of the Transient Receptor Potential Melastatin 2 (TRPM2) channel superagonist dADPR (2'-deoxy-ADPR, Cat. No. D 227). Both N-2'-dAD⁺ and dADPR were proved to be present in Jurkat T cells (all data according to Fliegert et al., Nat. Chem. Biol., 13, 1036 - 1044 (2017)). Reference: Alvarez-Gonzalez, R., Mol. Cell. Biochem., 138, 213 - 219 (1994).

Cat. No. N 065
CAS number [1514900-83-4]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -70°C / -94°F
Molecular formula C₂₁H₂₇N₇O₁₃P₂ (free acid)
Molecular weight [g/mol] 647.4 (free acid)
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 18000