The PDE-resistant protein kinase A activator Sp-cAMPS (Cat. No. A 003) immobilized on agarose by an aminohexylcarbamoyl spacer attached to the ribose 2'-position of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins, especially those which tolerate modification of the 2'-ribose hydroxyl group such as some phosphodiesterases. This type of gel is offered with a shorter spacer (Sp-2'-AEC-cAMPS-Agarose, Cat. No. A 122) as well. Detailed technical information available. Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.