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8- Bromo- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-2'-O-Me-cAMP-AM )
Metabolically activatable Epac agonist
Cat. No.: B 028
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: B 028-01
Unit: 1 µmol / ~0.5 mg
Extremely membrane-permeant precursor of the specific Epac agonist 8-Br-2'-O-Me-cAMP (Cat. No. B 022). After permeation and metabolic activation by esterases the active compound is released. Detailed technical information available. Reference: Börner et al., Nature Protocols, 6, 427 - 438 (2011).
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. B 028
CAS number [pending]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₄H₁₇BrN₅O₈P
Molecular weight [g/mol] 494.2
Modifications 8-cAMP, 2'-cAMP
Absorption max [nm] 264
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Komai A. M., Brännmark C., Musovic S.Olofsson C. S., J. Physiol., 0, 1 - 18 (2014), "PKA-independent cAMP Stimulation of White Adipocyte Exocytosis and Adipokine Secretion: Modulations by Ca2+ and ATP"
  • 2. Chepurny O. G., Bertinetti D., Diskar M., Leech C. A., Afshari P., Tsalkova T., Cheng X., Schwede F., Genieser H.-G., Herberg F. W.Holz G. G., Mol. Endocrinol., 27, 1267 - 1282 (2013), "Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag"
  • 3. Börner S., Schwede F., Schlipp A., Berisha F., Calebiro D., Lohse M. J.Nikolaev V. O., Nat. Protoc., 6, 427 - 438 (2011), "FRET Measurements of Intracellular cAMP Concentrations and cAMP Analog Permeability in Intact Cells"
  • 4. Nicol X., Hong K. P.Spitzer N. C., PNAS, 108, 13776 - 13781 (2011), "Spatial and Temporal Second Messenger Codes for Growth Cone Turning"