Membrane-permeant prodrug of inorganic phosphate. PO4-AM3 is recommended as control reagent in nucleotide-AM ester applications to test for side effects of acetic acid and formaldehyde. After permeation and intracellular metabolic activation by endogenous esterases the highly polar inorganic phosphate (PO43-) is released. In addition, the AM ester groups liberate acetic acid and formaldehyde, two metabolites with potential biological functions. References: Schultz et al., J. Biol. Chem., 268, 6316 - 6322 (1993); Chepurny et al., J. Biol. Chem., 284, 10728 - 10736 (2009).
Please note: 0.33 μmol of PO4-AM3 is stoichiometrically equivalent to 1 μmol of a cyclic nucleotide AM ester.
|Cat. No.||P 030|
|Purity||> 95% (MS)|
|Storage temperature||-20°C / -4°F|
|Molecular weight [g/mol]||314.2|