Membrane-permeant, metabolically activatable prodrug form of the potential further second messenger cyclic UMP (cUMP, Cat. No. U 001
). After permeation and metabolic activation by esterases the polar cUMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal. Detailed technical information available. Reference: Beckert et al., Biochem. Biophys. Res. Commun.
, 497 - 502 (2014).
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030
) which is recommended as control reagent in nucleotide-AM ester applications.