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8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-2'-O-Me-cAMP-AM )
Metabolically activatable, highly membrane-permeant Epac agonist
Cat. No.: C 051
CAS No.: [1152197-23-3]
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Cat. No.: C 051-01
Unit: 1 µmol / ~0.6 mg

Extremely membrane-permeant precursor of the specific Epac agonist 8-pCPT-2'-O-Me-cAMP (Cat. No. C 041). After permeation and metabolic activation by esterases the active compound 8-pCPT-2'-O-Me-cAMP is released. References: Vliem et al., ChemBioChem9, 2052 - 2054 (2008); Chepurny et al., J. Biol. Chem., 284, 10728 - 10736 (2009); Chepurny et al., Am. J.Physiol., 298, E622 - E633 (2010).

Related products: Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications. 6-Bnz-cAMP-AM (Cat. No. B 079) is a highly membrane-permeant specific activator of PKA and can be used as Epac-negative control.

Cat. No. C 051
Patent Information Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
CAS number [1152197-23-3]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₁ClN₅O₈PS
Molecular weight [g/mol] 557.9
Modifications 8-cAMP, 2'-cAMP
Target Epac Activator
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000