Extremely membrane-permeant precursor of the specific Epac agonist 8-pCPT-2'-O-Me-cAMP (Cat. No. C 041). After permeation and metabolic activation by esterases the active compound 8-pCPT-2'-O-Me-cAMP is released. References: Vliem et al., ChemBioChem, 9, 2052 - 2054 (2008); Chepurny et al., J. Biol. Chem., 284, 10728 - 10736 (2009); Chepurny et al., Am. J.Physiol., 298, E622 - E633 (2010).
Related products: Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications. 6-Bnz-cAMP-AM (Cat. No. B 079) is a highly membrane-permeant specific activator of PKA and can be used as Epac-negative control.
|Cat. No.||C 051|
|Patent Information||The reagent is protected under patent EP 1511757 and foreign equivalents issued or licensed to BIOLOG Life Science Institute.|
|Purity||> 97% HPLC for mixture of isomers|
|Storage temperature||-20°C / -4°F|
|Molecular weight [g/mol]||557.9|
|Absorption max [nm]||282|
|Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]||16000|