8- Bromoadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-cAMP-AM )

Metabolically activatable prodrug of the PKA agonist 8-Br-cAMP
Cat. No.: B 020   CAS No.: [190522-24-8]   
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C13H15BrN5O8P; MW 480.2; λmax 264 nm; ε 17000; purity > 97% HPLC for mixture of axial and equatorial isomer. A membrane-permeant precursor of the PKA activator 8-Br-cAMP (Cat. No. B 007). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. References: Kruppa et al., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006).

Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.

 



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