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8- Bromoguanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-cGMP-AM )
Membrane-permeant prodrug form of 8-Br-cGMP
Cat. No.: B 014
CAS No.: [272445-71-3]
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Cat. No.: B 014-01
Unit: 1 µmol / ~0.5 mg
Membrane-permeant precursor of the PKG activator 8-Br-cGMP (Cat. No. B 004). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. Reference: Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. B 014
CAS number [272445-71-3]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₅BrN₅O₉P
Molecular weight [g/mol] 496,2
Modifications 8-cGMP
Target PKA (cAK) Activator, PKG (cGK) Activator
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16200