Basket (0 Items) - Amount: 0.00$8- Bromoguanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-cGMP-AM )
Membrane-permeant prodrug form of 8-Br-cGMP
Cat. No.: B 014 CAS No.: [272445-71-3]
C13H15BrN5O9P; MW 496.2; λmax 260 nm; ε 16200; purity > 97% HPLC for mixture of axial and equatorial isomers. Membrane-permeant precursor of the PKG activator 8-Br-cGMP (Cat. No. B 004). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. Reference: Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000).
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
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