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8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-cGMP-AM )
Highly membrane-permeant prodrug form of the PKG agonist 8-pCPT-cGMP
Cat. No.: C 033
CAS No.: [272445-72-4]
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Cat. No.: C 033-01
Unit: 1 µmol / ~0.6 mg
Highly membrane-permeant precursor of the PKG activator 8-pCPT-cGMP (Cat. No. C 009). Metabolic activation by esterases releases the active analogue. Detailed technical information available. Reference: Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. C 033
CAS number [272445-72-4]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₉H₁₉ClN₅O₉PS
Molecular weight [g/mol] 559,9
Modifications 8-cGMP
Target PKG (cGK) Activator
Absorption max [nm] 276
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 21500
  • 1. Schwede F., Brustugun O. T., Zorn-Kruppa M., Doeskeland S. O.Jastorff B., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000), "Membrane-permeant, Bioactivatable Analogues of cGMP as Inducers of Cell Death in IPC-81 Leukemia Cells"