Membrane-permeant precursor of the second messenger cyclic GMP (Cat. No. G 001
). Metabolic activation by esterases releases the polar active analogue which is trapped inside the cell. In contrast to other membrane-permeant and PDE-resistant cGMP analogues, cGMP-AM yields a transient increase (pulse) of cGMP. Especially suitable for external triggering of cGMP-regulated phosphodiesterases (PDE II, III & V) where most cGMP analogues are not accepted. Detailed technical information available. Reference: Schwede et al., Bioorg. Med. Chem. Lett
, 571 - 573 (2000). Biolog also offers Phosphate tris(acetoxymethyl)ester
, Cat. No. P 030
) which is recommended as control reagent in nucleotide-AM ester applications.