Highly membrane-permeant precursor of the PKA activator 8-Br-cAMP (Cat. No. B 007). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. References: Kruppa et al., Bioorg. Med. Chem. Lett
, 945 - 948 (1997); Krakstad et al., J. Leukocyte Biol
, 641 - 647 (2004); Moll et al., J. Neural. Transm
, 1015 - 1032 (2006).
Biolog also offers Phosphate tris(acetoxymethyl)ester
, Cat. No. P 030
) which is recommended as control reagent in nucleotide-AM ester applications.