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8-Br-cAMP-AM

8- Bromoadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-cAMP-AM )
Metabolically activatable prodrug of the PKA agonist 8-Br-cAMP
Cat. No.: B 020
    
CAS No.: [190522-24-8]
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Product Name Price (net) Qty
Cat. No.: B 020-01
Unit: 1 µmol / ~0.5 mg
$134.00
Highly membrane-permeant precursor of the PKA activator 8-Br-cAMP (Cat. No. B 007). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. References: Kruppa et al., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997); Krakstad et al., J. Leukocyte Biol., 76, 641 - 647 (2004); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006).
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. B 020
CAS number [190522-24-8]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₅BrN₅O₈P
Molecular weight [g/mol] 480,2
Modifications 8-cAMP
Target PKA (cAK) Activator
Absorption max [nm] 264
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Moll D., Prinz A., Gesellchen F., Drewianka S., Zimmermann B.Herberg F. W., J. Neural. Transm., 113, 1015 - 1032 (2006), "Biomolecular Interaction Analysis in Functional Proteomics"
  • 2. Krakstad C., Chua N. H.Doeskeland S. O., J. Leukoc. Biol., 76, 641 - 647 (2004), "cAMP Protects Neutrophils against TNF-Alpha-induced Apoptosis by Activation of cAMP-dependent Protein Kinase, Independently of Exchange Protein Directly Activated by cAMP (EPAC)"
  • 3. Bartsch M., Zorn-Kruppa M., Kühl N., Genieser H.-G., Schwede F.Jastorff B., Biol. Chem., 384, 1321 - 1326 (2003), "Bioactivatable, Membrane-permeant Analogs of Cyclic Nucleotides as Biological Tools for Growth Control of C6 Glioma Cells"
  • 4. Krakstad C., Christensen A. E.Doeskeland S. O., Abstract of the 13th Protein Kinase Symposium p. 19, 0, 12 - 15 (2002), "cAMP Protects against Neutrophil Apoptosis via cAMP-dependent Protein Kinase Rather than Exchange Protein Directly Activated by cAMP (EPAC)"
  • 5. Kruppa J., Keely S., Schwede F., Schultz C., Barrett K. E.Jastorff B., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997), "Bioactivatable Derivatives of 8-Substituted cAMP-Analogues"
  • 6. Kruppa J., Ph. D. Thesis Bremen/Germany, 0, 0 - 0 (1996), "Neue Alkylierte cAMP-Derivate: Synthese und Biologische Eigenschaften"
  • 7. Brustugun O. T., Mellgren G.Doeskeland S. O., Abstract of 10th Protein Kinase Seminar, 0, 0 - 0 (1996), "Activation of cyclic AMP Dependent Protein Kinase in Swiss 3T3 Fibroblasts Evokes a Triphasic Response"