Basket (0 Items) - Amount: 0.00$8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-2'-O-Me-cAMP-AM )
C20H21ClN5O8PS; MW 557.9; λmax 282 nm; ε 16000; purity > 97% HPLC for mixture of isomers. Extremely membrane-permeant precursor of the specific Epac agonist 8-pCPT-2'-O-Me-cAMP (Cat. No. C 041). After permeation and metabolic activation by esterases the active compound is released. References: Vliem et al., ChemBioChem, 9, 2052 - 2054 (2008); Chepurny et al., J. Biol. Chem., 284, 10728 - 10736 (2009).
Related products: Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications. 6-Bnz-cAMP-AM (Cat. No. B 079) is a highly membrane-permeant specific activator of PKA and can be used as Epac-negative control.
Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
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