0 Items - $0.00
Categories
A to Z

Alternative structural projections:

8-pCPT-2'-O-Me-cAMP

8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-pCPT-2'-O-Me-cAMP ), sodium salt
Specific, membrane-permeant Epac activator
Cat. No.: C 041
    
CAS No.: [634207-53-7]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 041-05
Unit: 5 µmol / ~2.5 mg
$187.00

For other salt forms please inquire. Specific activator of the exchange protein activated by cyclic AMP (Epac) or cAMP-GEF, respectively, which does not activate protein kinase A. High lipophilicity and membrane permeability, as well as increased PDE stability. Potential metabolites are offered as well. Detailed technical information and updated references available. References: Enserink et al., Nature Cell Biol., 4, 901 - 906 (2002); Kang et al., J. Biol. Chem., 278, 8279 - 8285 (2003); Christensen et al., J. Biol. Chem., 278, 35394 - 35402 (2003).

Cat. No. C 041
Patent Information Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
CAS number [634207-53-7]
Purity >98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₁₆ClN₅O₆PS · Na
Molecular weight [g/mol] 507.8
Modifications 8-cAMP, 2'-cAMP
Target Epac Activator
Lipophilicity 2.95
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
  • 1. Schwede F., Bertinetti D., Langerijs C. N., Hadders M. A., Wienk H., Ellenbroek J. H., de Koning E. J. P., Bos J. L., Herberg F. W., Genieser H.-G., Janssen R. A.Rehmann H., PLoS Biol., 13, 1 - 26 (2015), "Structure-Guided Design of Selective Epac1 and Epac2 Agonists"
  • 2. Wolter S., Kloth C., Golombek M., Dittmar F., Försterling L.Seifert R., Biochem. Pharmacol., 98, 119 - 131 (2015), "cCMP Causes Caspase-dependent Apotosis in Mouse Lymphoma Cell Lines"
  • 3. Beckert U., Grundmann M., Wolter S., Schwede F., Rehmann H., Kaever V., Kostenis E.Seifert R., Biochem. Biophys. Res. Commun., 451, 497 - 502 (2014), "cNMP-AMs Mimic and Dissect Bacterial Nucleotidyl Cyclase Toxin Effects"
  • 4. Gausdal G., Wergeland A., Skavland J., Nguyen E., Pendino F., Rouhee N., McCormack E., Herfindal L., Kleppe R., Havemann U., Schwede F., Bruseud O., Gjertsen B. T., Lanotte M., Segal-Bendirdjian E.Doskeland S. O., Cell Death Dis., 4, 0 - 0 (2013), "Cyclic AMP Can Promote APL Progression and Protect Myeloid Leukemia Cells Against Anthracycline-Induced Apoptosis"
  • 5. Lee T.-M., Lin S.-Z.Chang N.-C., PLoS ONE, 8, 0 - 0 (2013), "Both PKA and Epac Pathways Mediate N-Acetylcystine-Induced Connexin43 Preservation in Rats with Myocardial Infarction"
  • 6. Chepurny O. G., Bertinetti D., Diskar M., Leech C. A., Afshari P., Tsalkova T., Cheng X., Schwede F., Genieser H.-G., Herberg F. W.Holz G. G., Mol. Endocrinol., 27, 1267 - 1282 (2013), "Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag"
  • 7. Courilleau D., Bouyssou P., Fischmeister R., Lezoualc'h F.Blondeau J.-P., Biochem. Biophys. Res. Commun., 440, 443 - 448 (2013), "The (R)-Enantiomer of CE3F4 is a Preferential Inhibitor of Human Exchange Protein Directly Activated by Cyclic AMP Isoform 1 (Epac1)"
  • 8. Rehmann H., Sci. Rep., 3: 3032, 0, 0 - 0 (2013), "Epac-Inhibitors: Facts and Artefacts"
  • 9. Herfindal L., Nygaard G., Kopperud R., Krakstad C., Doeskeland S. O.Selheim F., Biochem. Biophys. Res. Commun., 437, 603 - 608 (2013), "Off-Target Effect of the Epac Agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 Receptors in Blood Platelets"
  • 10. Tsalkova T., Mei F. C.Cheng X., PloS ONE, 7, 0 - 0 (2012), "A Fluorescence-Based High-Throughout Assay for the Discovery of Exchange Protein Directly Activated by cyclic AMP (Epac) Antagonists"
  • 11. Tang Z. H., Shi D. Y., Jia B. B., Chen J. R., Zong C., Shen D., Zheng Q., Wang J. F.Tong X. M., Int. J. Biochem. Cell. Biol., 44, 1106 - 1120 (2012), "Exchange Protein Activated by Cyclic Adenosine Monophosphate Regulates the Switch between Adipogenesis and Osteogenesis of Human Mesenchymal Stem Cells through Increasing the Activation of Phosphatidylinositol 3-Kinase"
  • 12. Menon J., Doebele R. C., Gomes S., Bevilacqua E., Reindl K. M.Rosner M. R., PLoS One, e49893, 7, 0 - 0 (2012), "A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer"
  • 13. Ying Y., Li L., Cao W., Yan D., Zeng Q., Kong X., Lu L., Yan M., Xu X., Qu J., Su Q.Ma X. S., FEBS Lett., 586, 3674 - 3680 (2012), "The Microtubule Associated Protein Syntabulin is Required for Glucose-Stimulated and cAMP-Potentiated Insulin Secretion"
  • 14. Roscioni S. S., Prins A. G., Elzinga C. R. S., Menzen M. H., Dekkers B. G. J., Halayko A. J., Meurs H., Maarsingh H.Schmidt M., Br. J. Pharmacol., 164, 958 - 969 (2011), "Protein Kinase A and the Exchange Protein Directly Activated by cAMP (EPAC) Modulate Phenotype Plasticity in Human Airway Smooth Muscle"
  • 15. Roscioni S. S., Dekkers B. G. J., Prins A. G., Menzen M. H., Meurs H., Schmidt M.Maarsingh H., Br. J. Pharmacol., 162, 193 - 209 (2011), "cAMP inhibits Modulation of Airway Smooth Muscle Phenotype via the Exchange Protein Activated by cAMP(EPAC) and Protein Kinase A"
  • 16. Mukai E., Fujimoto S., Sato H., Oneyama C., Kominato R., Sato Y., Sasaki M., Nishi Y., Okada M.Inagaki N., Diabetes., 60, 218 - 226 (2011), "Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-dependent Manner"
  • 17. Fukuda M., Williams K. W., Gautron L.Elmquist J. K., Cell Metab., 13, 331 - 339 (2011), "Induction of Leptin Resistance by Activation of cAMP-Epac Signaling"
  • 18. Harmati G., Benyasz T., Barandi L., Szentandrassy N., Horvath B., Szabo G., Szentmiklosi J. A., Szenasi G., Nanasi P. P.Magyar J., Br. J. Pharmacol., 162, 890 - 896 (2011), "Effect of Beta-Adrenoceptor Stimulation on Delayed Rectifier K Plus Currents in Canine Ventricular Cardiomyocytes"
  • 19. Aerts I., Grobben B., van Ostade X.Slegers H., Eur. J. Pharmacol., 654, 1 - 9 (2011), "Cyclic AMP-dependent Down Regulation of Ecto-Nucleotide Pyrophosphatase/ Phosphodiesterase 1 (NPP1) in Rat C6 Glioma"
  • 20. Zieba B. J., Artamonov M. V., Jin L., Momotani K., Ho R., Franke A. S., Neppl R. L., Stevenson A. S., Khromov A. S., Chrzanowska-Wodnicka M.Somlyo A. V., J. Biol.Chem., 286, 16681 - 16692 (2011), "The cAMP-Responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity"
  • 21. Roscioni S. S., Maarsingh H., Elzinga C. R. S., Schuur J., Menzen M., Halayko A. J., Meurs H.Schmidt M., J. Cell. Mol. Med., 15, 1551 - 1563 (2011), "Epac as a Novel Effector of Airway Smooth Muscle Relaxation"
  • 22. Huseby S., Gausdal G., Keen T. J., Kjærland E., Krakstad C., Myhren L., Brønstad K., Kunick C., Schwede F., Genieser H.-G., Kleppe R.Doeskeland S. O., Cell Death Dis., e237, 2, 0 - 0 (2011), "Cyclic AMP Induces IPC Leukemia Cell Apoptosis via CRE-and CDK-dependent Bim Transcription"
  • 23. Enyeart J. A., Liu H.Enyeart J. J., Am. J. Physiol. Endocrinol. Metab., 301, 941 - 954 (2011), "8-Phenylthio-adenines Stimulate the Expression of Steroid Hydroxylases, Cav3.2 Ca2+ Channels, and Cortisol Synthesis by a cAMP-independent Mechanism"
  • 24. Ostroveanu A., van der Zee E. A., Eisel U. L., Schmidt M.Nijholt I. M., Hippocampus, 9, 1018 - 1026 (2010), "Exchange Protein Activated by cyclic AMP 2 (Epac2) Plays a Specific and Time-limited Role in Memory Retrieval"
  • 25. Liu H., Enyeart J. J.Enyeart J. A., J. Biol. Chem., 285, 20040 - 20050 (2010), "ACTH Induces CAv3.2. Current and mRNA by cAMP-dependent and cAMP-independent Mechanism"
  • 26. Lim J.-G., Lee J.-J., Park S.-H., Park J.-H., Kim S.-J., Cho H.-C., Baek W.-K., Kim D.-K.Song D.-K., Neurosci. Lett., 479, 13 - 17 (2010), "Glucagon-like Peptide-1 Protecs NSC-34 Motor Neurons against Glucosamine through Epac-mediated Uptake Enhancement"
  • 27. Rah S.-Y., Mushtaq M., Nam T.-S., Kim S. H.Kim U.-H., J. Biol. Chem., 285, 21877 - 21887 (2010), "Generation of Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by CD38 for Ca2+ Signaling in Interleukin-8-treated Lymphokine-activated Killer Cells"
  • 28. Idevall-Hagren O., Barg S., Gylfe E.Tengholm A., J. Biol. Chem., 285, 23007 - 23018 (2010), "cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single Beta-cells"
  • 29. Seino S., Shibasaki T.Minami K., Proceed. Jap. Acad. Series B-Physical and Biological Sci., 86, 563 - 577 (2010), "Pancreatic Beta-cell Signaling: Toward Better Understanding of Diabetes and its Treatment"
  • 30. Kim S.-P., Ha J. M., Yun S. J., Kim E. K., Chung S. W., Hong K. W., Kim C. D.Bae S. S., Biochem. Biophys. Res. Commun., 399, 55 - 59 (2010), "Transcriptional Activation of Peroxisome Proliferator-activated Receptor-gamma Requires Activation of Both Protein Kinase A and Akt During Adipocyte Differentiation"
  • 31. Duquesnes N., Derangeon M., Metrich M., Lucas A., Mateo P., Li L., Morel E., Lezoualc'h F.Crozatier B., Pflugers Arch.-Eur. J. Physiol., 460, 731 - 741 (2010), "Epac Stimulation Induces Rapid Increases in Connexin43 Phosphorylation and Function without Preconditioning"
  • 32. Garay J., D'Angelo J. A., Park Y., Summa C. M., Aiken M. L., Morales E., Badizadegan K., Fiebiger E.Dickinson B. L., J. Immunol., 185, 3227 - 3238 (2010), "Crosstalk Between PKA and Epac Regulates the Phenotypic Maturation and Function of Human Dendritic Cells"
  • 33. Yoshie M., Kaneyama K., Kusama K., Higuma C., Nishi H., Isaka K.Tamura K., Human Reproduction, 25, 2229 - 2238 (2010), "Possible Role of the Exchange Protein Directly Activated by Cyclic AMP (Epac) in the Cyclic AMP-dependent Functional Differentiation and Syncytialization of Human Placental BeWo Cells"
  • 34. Shi G.-X., Jin L.Andres D. A., Mol. Biol. Cell, 21, 1597 - 1608 (2010), "Src-dependent TrkA transaction is Required for Pituiary Adenylate Cyclase-activation Polypeptide 38-mediated Rit Activation and Neuronal Differentiation"
  • 35. Bernascone S., Erriquez J., Ferraro M., Genazzani A.Distasi C., Cell Calcium, 48, 83 - 90 (2010), "Novel Adenosine and cAMP Signalling Pathways in Migrating Glial Cells"
  • 36. Spaeth C. S., Boydston E. A., Figard L. R., Zuzek A.Bittner G. D., J. Neurosci., 30, 15790 - 15800 (2010), "A Model for Sealing Plasmalemmal Damage in Neurons and Other Eukaryotic Cells"
  • 37. Gerlo S., Verdood P.Kooijman R., J. Interferon Cytokine Res., 30, 883 - 891 (2010), "Modulation of Cytokine Production by Cyclic Adenosine Monophosphate Analogs in Human Leukocytes"
  • 38. Dzhura I., Chepurny O. G., Kelley G. G., Leech C. A., Roe M. W., Dzhura E., Afshari P., Malik S., Rindler M. J., Xu X., Lu Y., Smrcka A. V.Holz G. G., J. Physiol., 588, 4871 - 4889 (2010), "EPAC2-dependent Mobilization of Intracellular Ca2+ by Glucagon-like Peptide-1 Receptor Agonist Exendin-4 is Disrupted in Beta-Cells of Phospholipase C-Epsilon Knockout Mice"
  • 39. Eijkelkamp N., Wang H. J., Garza-Carbajal A., Willemen H. L. D. M., Zwartkruis F. J., Wood J. N., Dantzer R., Kelley K. W., Heijnen C. J.Kavelaars A., J. Neurosci., 30, 12806 - 12815 (2010), "Low Nociceptor GRK2 Prolongs Prostaglandin E-2 Hyperalgesia via Biased cAMP Signaling to epac/Rap1, Protein Kinase C Epsilon, and MEK/ERK"
  • 40. Lissitzky J. C., Parriaux D., Ristorcelli E., Verine A., Lombardo D.Verrando P., Cancer Res., 69, 802 - 809 (2009), "Cyclic AMP Signaling as a Mediator of Vasculogenic Mimicry in Agressive Human Melanoma Cells in Vitro"
  • 41. Purves G. I., Kamishima T., Davies L. M., Quayle J. M.Dart C., J. Physiol., 587, 3639 - 3650 (2009), "Exchange Protein Activated by cAMP (Epac) Mediates cAMP-dependent but Protein Kinase A Insensitive Modulation of Vascular ATP-sensitive Potassium Channels"
  • 42. Ma N., Abel T.Hernandez P. J., Learning Mem., 16, 367 - 370 (2009), "Exchange Protein Activated by cAMP Enhances Long-term Memory Formation Independent of Protein Kinase A"
  • 43. Tcivileva I. E., Tan K. S., Gambarian M., Nackley A. G., Medvedev A. V., Romanov S., Flood P. M., Maixner W., Makarov S. S.Diatchenko L., Mol. Immuno., 46, 2256 - 2266 (2009), "Signaling Pathway Mediating beta(3)-adrenergic Receptor-induced Production of Interleukin-6 in Adipocytes"
  • 44. Peters-Golden M., Sci. Signal, 2, 0 - 0 (2009), "Putting on the Brakes: cyclic AMP as a Multipronged Controller of Macrophage Function"
  • 45. Doebele R. C., Schulze-Hoepfner F. T., Hong J., Chlenski A., Zeitlin B. D., Goel K., Gomes S., Liu Y., Abe M. K., Nor J. E., Lingen M. W.Rosner M. R., Blood, 114, 4592 - 4600 (2009), "A Novel Interplay between Epac/Rap1 and MEK5/ERK5 Regulates Thrombospondin to Control Angiogenesis"
  • 46. Hinke S. A., Sci. Signal., 2(85):pe54., 2, 0 - 0 (2009), "Epac2: A Molecular Target for Sulfonylurea-induced Insulin Release"
  • 47. Bogatcheva N. V., Zemskova M. A., Kovalenkov Y., Poirier C.Verin A. D., J. Cell. Physiol., 221, 750 - 759 (2009), "Molecular Mechanism Mediating Protective Effect of cAMP on Lipopolysaccharide (LPS)-induced Human Lung Microvascular Endothelial Cells (HLMVEC) Hyperpermeability"
  • 48. Baumer Y., Spindler V., Werthmann R. C., Bünemann M.Waschke J., J. Cell. Physiol., 220, 716 - 726 (2009), "Role of Rac 1 and cAMP in Endothelial Barrier Stabilization and Thrombin-Induced Barrier Breakdown"
  • 49. Misra U. K.Pizzo S. V., J. Cell. Biochem., 108, 998 - 1011 (2009), "Epac1-induced Cellular Proliferation in Prostate Cancer Cells is Mediated by B-Raf/ERK and mTOR Signaling Cascades"
  • 50. Oestreich E. A., Malik S., Goonasekera A., Blaxall B. C., Kelley G. G., Dirksen R. T.Smrcka A. V., J.Bio.Chem., 284, 1514 - 1522 (2009), "Epac and Phospholipase C-etheno Regulate CA2+ Release in the Heart by Activation of Protein Kinase C-etheno and Calcium-calmodulin-KinaseII"
  • 51. Sarkar S., Ravikumar B., Floto R. A.Rubinsztein D. C., Cell Death Differ., 16, 46 - 56 (2009), "Rapamycin and mTOR-independent Autophagy Inducers Ameliorate Toxicity of Polyglutamine-expanded Huntington and Related Proteinopathies"
  • 52. Scheibner K. A., Boodoo S., Collins S., Black K. E., Chan-Li Y., Zarek P., Powell J. D.Horton M. R., Am. J. Respir. Cell Mol. Biol., 40, 251 - 259 (2009), "The Adenosine A2a Receptor Inhibits Matrix Induced Inflammation in a Novel Fashion"
  • 53. Chepurny O. G., Leech C. A., Kelley G. G., Dzhura I., Dzhura E., Li X., Rindler M. J., Schwede F., Genieser H.-G.Holz G. G., J. Biol. Chem., 284, 10728 - 10736 (2009), "Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: Studies with 8-pCPT-2'-O-Me-cAMP-AM."
  • 54. Choi J. H., Chen C. L., Poon S. L., Wang H. S.Leung P. C., Endocr. Relat. Cancer, 16, 179 - 188 (2009), "Gonadotropin-stimulated EGFR Expression in Human Ovarian Surface Epithelial Cells: Involvement of cyclic AMP-dependent Epac Pathway"
  • 55. Banales J. M., Masyuk T. V., Gradilone S. A., Masyuk A. I.LaRusso N. F., Hepatology, 49, 160 - 174 (2009), "The cAMP Effectors Epac and Protein Kinase A (PKA) are Involved in the Hepatic Cystogenesis of an Animal Model of Autosomal Recessive Polycystic Kidney Disease (ARPKD)"
  • 56. Ster J., De Bock F., Bertaso F., Abitbol K., Daniel H., Bockaert J.Fagni L., J. Physiol., 587, 101 - 113 (2009), "Epac Mediates Pacap-dependent Long-term Depression in the Hippocampus"
  • 57. Omar B., Zmuda-Trzebiatowska E., Manganiello V. C., Göransson O.Degerman E., Cell Signal, 5, 760 - 766 (2009), "Regulation of AMP-activated Protein Kinase by cAMP in Adipocytes: Roles for Phosphodiesterases, Protein Kinase B, Protein Kinase A, Epac and Lipolysis"
  • 58. Grandoch M., de Jesus B. M., Oude Weernink P. A., Weber A. A., Jakobs K. H.Schmidt M., Cell Signal, 4, 609 - 621 (2009), "B Cell Receptor-induced Growth Arrest and Apoptosis in WEHI-231 Immature B Lymphoma Cells Involve Cyclic AMP and Epac Proteins"
  • 59. Kelly M. P., Stein J. M., Vecsey C. G., Favilla C., Yang X., Bizily S. F., Esposito M. F., Wand G., Kanes S. J.Abel T., Mol. Psychiatry, 14, 398 - 415 (2009), "Developmental Etiology for Neuroanatomical and Cognitive Deficits in Mice Overexpressing G Alpha S, a G-protein Subunit Genetically Linked to Shizophrenia"
  • 60. Kojima F., Kapoor M., Kawai S., Yang L., Aronoff D. M.Crofford L. J., Prostaglandins Other Lipid Mediat., 89, 26 - 33 (2009), "Prostaglandin E (2) Activates Rap1 via EP2/EP4 Receptors and cAMP-signaling in Rheumatoid Synovial Fibroblasts: Involvement of Epac1 and PKA"
  • 61. Branham M. T., Bustos M. A., De Blas G. A., Rehmann H., Zarelli V. E., Trevino C. L., Darszon A., Mayorga L. S.Tomes C. N., J. Biol. Chem., 284, 24825 - 24839 (2009), "Epac Activates the Small G Proteins Rap1 and Rab3A to Achieve Exocytosis"
  • 62. Enyeart J. A.Enyeart J. J., PloS One, 4, 0 - 0 (2009), "Metabolites of an Epac-Selective cAMP Analog Induce Cortisol Synthesis by Adrenocortical Cells through a cAMP-Independent Pathway"
  • 63. Bastian P., Balcarek A., Altanis C., Strell C., Niggemann B., Zänker K. S.Entschladen F., Cancer Lett., 274, 1218 - 1234 (2009), "The Inhibitory Effect of Norepinephrine on the Migration of ES-2 Ovarian Carcinoma Cells Involves a Rap1-dependent Pathway"
  • 64. Borland G., Smith B. O.Yarwood S. J., Brit. J. Pharmacol., 158, 70 - 86 (2009), "Epac Proteins Transduce Diverse Cellular Actions of cAMP"
  • 65. Kelley G. G., Chepurny O. G., Schwede F., Genieser H.-G., Leech C. A., Roe M. W., Li X., Dzhura I., Dzhura E., Afshari P.Holz G. G., Islets, 1, 260 - 265 (2009), "Glucose-dependent Potentation of Mouse Islet Insulin Secretion by Epac Activator 8-pCPT-2'-O-Me-cAMP-AM"
  • 66. Waidmann O., Pleli T., Dvorak K., Baehr C., Mondorf U., Plotz G., Biondi R. M., Zeuzem S.Piiper A., J.Biol.Chem., 284, 32256 - 32263 (2009), "Inhibition of the Equilibrative Nucleoside Transporter 1 and Activation of A2A Adenosine Receptors by 8-(4-Chlorophenylthio)-modified cAMP Analogs and their Hydrolytic Products"
  • 67. Lefkimmiatis K., Moyer M. P., Curci S.Hofer A. M., PLoS One, 4, 0 - 0 (2009), "'cAMP sponge': a Buffer for Cyclic Adenosine 3', 5'-monophosphate"
  • 68. Whitaker C. M.Wei H., J. Physiol., 587, 3067 - 3068 (2009), "An alternate cAMP pathway Epac promotes hippocampal long-term depression"
  • 69. Yeager L. A., Chopra A. K.Peterson J. W., Infect. Immun., 77, 2530 - 2543 (2009), "Bacillus anthracis Edema Toxin Suppresses Human Macrophage Phagocytosis and Cytoskeletal Remodeling via the Protein Kinase A and Exchange Protein Activated by Cyclic AMP Pathways"
  • 70. Carmona G., Chavakis E., Koehl U., Zeiher A. M.Dimmeler S., Blood, 111, 2640 - 2646 (2008), "Activation of Epac Stimulates Integrin-dependent Homing of Progenitor Cells"
  • 71. Monaghan T. K., Mackenzie C. J., Plevin R.Lutz E. M., J. Neurochem., 104, 74 - 88 (2008), "PACAP-38 Induces Neuronal Differentiation of Human SH-SY5Y Neuroblastoma Cells via cAMP-mediated Activation of ERK and p38 MAP Kinases"
  • 72. Brock T. G., Serezani C. H., Carstens J. K., Peters-Golden M.Aronoff D. M., Exp. Cell. Res., 314, 255 - 263 (2008), "Effects of Prostaglandin E(2)on the Subcellular Localization of Epac-1 and Rap1 Proteins during Fcgamma-Receptor-mediated Phagocytosis in Alveolar Macrophages"
  • 73. Rein J., Voss M., Blenau W., Walz B.Baumann O., Am. J. Physiol. Cell. Physiol., 294, 56 - 65 (2008), "Hormone-induced Assembly and Activation of V-ATPase in Blowfly Salivary Glands is Mediated by Protein Kinase A"
  • 74. Misra U. K., Kaczowka S.Pizzo S. V., Cell. Signal, 20, 1459 - 1470 (2008), "The cAMP-activated GTP Exchange Factor, Epac1 Upregulates Plasma Membrane and Nuclear Akt Kinase Activitites in 8-CPT-2-O-Me-cAMP-stimulated Macrophages: Gene Silencing of the cAMP-activated GTP Exchange Epac1 Prevents 8-CPT-2-O-cAMP Activity in Macrophages"
  • 75. Harper S. M., Wienk H., Wechselberger R. W., Bos J. L., Boelens R.Rehmann H., J. Biol. Chem., 283, 6501 - 6508 (2008), "Structural Dynamics in the Activation of EPAC"
  • 76. Huang S. K., Wettlaufer S. H., Chung J.Peters-Golden M., Am. J. Respir. Cell Mol. Biol., 39, 482 - 489 (2008), "Prostaglandin E2 Inhibits Specific Lung Fibroblast Functions Via Selective Actions of PKA and Epac-1"
  • 77. Aivatiadou E., Ripolone M., Brunetti F.Berruti G., Mol. Reprod. Dev., 76, 407 - 416 (2008), "cAMP-Epac2-mediated Activation of Rap1 in Developing Male Germ Cells: RA-RhoGAP as a Possible Direct Down-Stream Effector"
  • 78. Shah A. U., Grant W. M., Latif S. U., Mannan Z. M., Park A. J.Husain S. Z., Am. J. Phys. Gastro. Liver Phys., 294, 1328 - 1334 (2008), "Cyclic-AMP Accelerates Calcium Waves in Pancreatic Acinar Cells"
  • 79. Baumer Y., Drenckhahn D.Waschke J., Histochem. Cell Biol., 129, 765 - 778 (2008), "cAMP-induced Rac 1-mediated Cytoskeletal Reorganization in Microvascular Endothelium"
  • 80. Searl T. J.Silinsky E. M., J. Neurophysiol., 99, 2779 - 2788 (2008), "Mechanism of Neuromodulation as Dissected Using Sr2+ at Motor Nerve Endings"
  • 81. Yokoyama U., Patel H. H., Lai N. C., Aroonsakool N., Roth D. M.Insel P. A., PNAS, 105, 6386 - 6391 (2008), "The cyclic AMP Effector Epac Integrates Pro- and Anti-fibrotic Signals"
  • 82. Kamio K., Sato T., Liu Y. J., Sugiura H., Togo S., Kobayashi T., Wang X., Mao L., Ahn Y., Holz O., Magnussen H.Rennard S. I., Am. J. Physiol. Cell. Mol. Physiol. L, 294, 1226 - 1236 (2008), "Prostacyclin Analogues Stimulate Vascular Endothelial Growth Factor (VEGF) Production from Human Lung Fibroblasts in Culture"
  • 83. Eid A. H., Chotani M. A., Mitra S., Miller T. J.Flavahan N. A., Am. J. Physiol. Heart Circ. Physiol., 295, 266 - 272 (2008), "Cyclic AMP Acts through Rap1 and JNK Signaling to Increase Expression of Cutaneous Smooth Muscle {alpha}2C-Adrenoceptors"
  • 84. Poppe H., Rybalkin S. D., Rehmann H., Hinds T. R., Tang X.-B., Christensen A. E., Schwede F., Genieser H.-G., Bos J. L., Doeskeland S. O., Beavo J. A.Butt E., Nature Methods, 5, 277 - 278 (2008), "Cyclic Nucleotide Analogs as Probes of Signaling Pathways"
  • 85. Holz G. G., Chepurny O. G.Schwede F., Cell. Signal., 20, 10 - 20 (2008), "Epac-selective cAMP Analogs: New Tools with which to Evaluate the Signal Transduction Properties of cAMP-regulated Guanine Nucleotide Exchange Factors"
  • 86. Lyle K. S., Raaijmakers J. H., Bruinsma W., Bos J. L.de Rooij J., Cell. Signal., 20, 1104 - 1116 (2008), "cAMP-induced Epac-Rap Activation Inhibits Epithelial Cell Migration by Modulating Focal Adhesion and Leading Edge Dynamics"
  • 87. Kwak H.-J., Park K.-M., Choi H.-E., Chung K.-S., Lim H.-J.Park H.-Y., Cell. Signal., 20, 803 - 814 (2008), "PDE4 Inhibitor Roflumilast Protects Cardiomyocytes against NO-induced Apotosis via Activation of PKA and Epac Dual Pathway"
  • 88. Racke K., Haag S., Bahulayan A.Warnken M., Naunyn-Schmiedeberg's Arch. Pharmacol., 378, 193 - 201 (2008), "Pulmonary Fibroblasts, an Emerging Target for Anti-obstructive Drugs"
  • 89. Gelinas J. N., Banko J. L., Peters M. M., Klann E., Weeber E. J.Nguyen P. V., Learn. Mem., 15, 403 - 411 (2008), "Activation of Exchange Protein Activated by cyclic-AMP Enhances Long-lasting Synaptic Potentation in the Hippocampus"
  • 90. Li Y., Konings I. B. M., Zhao J., Price L. S., de Heer E.Deen P. M. T., Am. J. Physiol. Renal. Physiol., 295, 0 - 0 (2008), "Renal Expression of Exchange Protein Directly Activated by cAMP (Epac) 1 and 2"
  • 91. Kang G., Leech C. A., Chepurny O. G., Coetzee W. A.Holz G. G., J. Physiol., 587, 1307 - 1319 (2008), "Role of the cAMP Sensor Epac as a Determinant of K-ATP Channel ATP-Sensitivity in Human Pancreatic β-Cells and RAT INS-1 Cells"
  • 92. Vliem M. J., Ponsioen B., Schwede F., Pannekoek W.-J., Riedl J., Kooistra M. R. H., Jalink K., Genieser H.-G., Bos J. L.Rehmann H., ChemBioChem, 9, 2052 - 2054 (2008), "8-pCPT-2'-O-Me-cAMP-AM: An Improved Epac-selective cAMP Analogue"
  • 93. Liu H., Enyeart J. A.Enyeart J. J., J. Gen. Physiol., 132, 279 - 294 (2008), "ACTH Inhibits bTREK-1 K+Channels through Multiple cAMP-dependent Signaling Pathway"
  • 94. Petersen R. K., Madsen L., Pedersen L. M., Hallenborg P., Hagland H., Viste K., Doeskeland S. O.Kristiansen K., Mol. Cell. Biol., 28, 3804 - 3816 (2008), "Cyclic AMP (cAMP)-Mediated Stimulation of Adipocyte Differentiation Requires the Synergistic Action of Epac- and cAMP-Dependent Protein Kinase-Dependent Processes"
  • 95. Metrich M., Lucas A., Gastineau M., Samuel J.-L., Heymes C., Morel E.Lezoualc'h F., Circ. Res., 102, 959 - 965 (2008), "Epac Mediates Beta-Adrenergic Receptor-Induced Cardiomyocyte Hypertrophy"
  • 96. Roscioni S. S., Elzinga C. R. S.Schmidt M., Naunyn.-Schmied. Arch. Pharmacol., 377, 345 - 357 (2008), "Epac. Effectors and Biological Functions"
  • 97. Yarwood S. J., Borland G., Sands W. A.Palmer T. M., J. Biol. Chem., 283, 6843 - 6853 (2008), "Identification of C/EBPS as Epac-Activated Transcription Factors that Mediate the Induction of the SOC-3 Gene"
  • 98. Lezoualc'h F., Metrich M., Hmitou I., Duquesnes N.Morel E., J. Mol. Cell. Cardiol., 44, 623 - 632 (2008), "Small GTP-binding Proteins and their Regulators in Cardiac Hypertrophy"
  • 99. Sehrawat S., Cullere X., Patel S., Italiano J.Mayadas T. N., Mol. Biol. Cell., 19, 1261 - 1270 (2008), "Role of Epac1, an Exchange Factor for Rap GTPases, in Endothelial Microtubule Dynamics and Barrier Function"
  • 100. Zein N. E., Badran B.Sariban E., J. Leukoc. Biol., 83, 972 - 981 (2008), "VIP Differentially Activates Beta2 Integrins, CR1, and Matrix Metallproteinase-9 in Human Monocytes through cAMP/PKA, Epac, and PI-3K Signaling Pathway via VIP Receptor Type1 and FPRL1"
  • 101. O'Neill J. S., Maywood E. S., Chesham J. E., Takahashi J. S.Hastings M. H., Science, 320, 949 - 953 (2008), "cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker"
  • 102. Schmidt R., Baumann O.Walz B., BMC Physiol., 8, 1 - 27 (2008), "cAMP Potentiates InsP3-induced Ca2+ Release from the Endoplasmic Reticulum in Bowfly Salvary Glands"
  • 103. Ouyang M., Zhang L., Zhu J. J., Schwede F.Thomas S. A., PNAS, 105, 11993 - 11997 (2008), "Epac Signaling is Required for Hippocampus-dependent Memory Retrieval"
  • 104. Yokoyama U., Minamisawa S., Quan H., Akaike T., Jin M., Otsu K., Ulucan C., Wang X., Baljinnyam E., Takaoka M., Sata M.Ishikawa Y., Am. J. Physiol. Heart Circ. Physiol., 295, 1547 - 1555 (2008), "Epac1 is Upregulated During Neointima Formation and Promotes Vascular Smooth Mucle Cell Migration"
  • 105. Yokoyama U., Minamisawa S., Quan H., Akaike T., Suzuki S., Jin M., Watanabe M., Otsu K., Iwasaki S., Nishimaki S., Sato M.Ishikawa Y., J. Biol. Chem., 283, 28702 - 28709 (2008), "PGE2-activated Epac Promotes Neointimal Cushion Formation of the Rat Ductus Arteriosus by a Process Distinct from that of PKA"
  • 106. Haag S., Warnken M., Juergens U. R.Racke K., Naunyn-Schmiedeberg's Arch. Pharmacol., 378, 617 - 630 (2008), "Role of Epac1 in Mediating Anti-proliferative Effects of Prostanoid EP2 Receptors and cAMP in Human Lung Fibroblasts"
  • 107. Gekel I.Neher E., J. Neurosci., 28, 7991 - 8002 (2008), "Application of an Epac Activator Enhances Neurotransmitter Release at Excitatory Central Synapses"
  • 108. Faour W. H., Gomi K.Kennedy C. R. J., Cell. Signal., 20, 2156 - 2164 (2008), "PGE2 Induces COX-2 Expression in Podocytes via the EP4 Receptor through a PKA-independent Mechanism"
  • 109. Hothi S. S., Gurung I. S., Heathcote J. C., Zhang Y., Booth S. W., Skepper J. N., Grace A. A.Huang C. L.-H., Pflugers Arch. Eur. J. Physiol., 457, 253 - 270 (2008), "Epac Activation, Altered Calcium Homeostasis and Ventricular Arrthymogenesis in the Murine Heart"
  • 110. McPartlih L. A.Bedford-Guaus S. J., Theriogenology, 70, 576 - 591 (2008), "Soluble Adenylate Cyclase Generated cAMP Acts via Protein Kinase-A and not Epac 1/2 to Direct Capacitation-associated Protein Tyrosine Phosphorylation in Stallion Sperm"
  • 111. Kamio K., Liu X., Sugiura H., Togo S., Kobayashi T., Kawasaki S., Wang X. Q., Mao L., Ahn Y., Hogaboam C. M., Toews M. L.Rennard S. I., Am. J. Respir. Cell. Mol. Biol., 37, 113 - 120 (2007), "Prostacyclin Analogues Inhibit Fibroblast Contraction of Collagen Gels Through the cAMP-PKA Pathway"
  • 112. Tan K. S., Nackley A. G., Satterfield K., Maixner W., Diatchenko L.Flood P. M., Cell Signal, 19, 251 - 260 (2007), "Beta(2) Adrenergic Receptor Activation Stimulates Pro-inflammatory Cytokine Production in Macrophages via PKA- and NF-kappa B-independent Mechanism"
  • 113. Huang S. K., Wettlaufer S. H., Hogaboam C. M., Aronoff D. M.Peters-Golden M., Am. J. Physiol. Lung Cell Mol. Physiol., 292, 405 - 413 (2007), "Prostaglandin E2 Inhibits Collagen Expression and Proliferation in Patient-derived Normal Lung Fibroblasts Via E Prostanoid 2 Receptor and cAMP Signaling"
  • 114. Li J., O'Connor K. L., Cheng X., Mei F. C., Uchida T., Townsend C. M.Evers B. M., Mol. Endocrinol., 21, 159 - 171 (2007), "Cyclic AMP-stimulated Neurotensin Secretion is Mediated Through Rap1 Downstream of Both Epac and PKA Signaling Pathways"
  • 115. Brock M., Fan F., Mei F. C., Li S., Gessner C., Woods V. L.Cheng X. D., J. Biol. Chem., 282, 32256 - 32263 (2007), "Confirmational Analysis of Epac Activation Using Amide Hydrogen/Deuterium Exchange Mass Spectrometry"
  • 116. Rehmann H., Wittinghofer A.Bos J. L., Nat. Rev. Mol. Cell Biol., 8, 63 - 73 (2007), "Capturing Cyclic Nucleotides in Action: Snapshots from Crystallographic Studies"
  • 117. Oestreich E. A., Wang H., Malik S., Kaproth-Joslin K. A., Blaxall B. C., Kelley G. G., Dirksen R. T.Smrcka A. V., J. Biol. Chem., 282, 5488 - 5495 (2007), "Epac-mediated Activation of Phospholipase C-epsilon Plays a Critical Role in Beta-adrenergic Receptor Dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes"
  • 118. Norum J. H., Dawood H., Mattingly R. R., Sandnes D.Levy F. O., FEBS Lett., 581, 15 - 20 (2007), "Epac- and Rap-independent ERK1/2 Phosphorylation Induced by Gs-coupled Receptor Stimulation in HEK293 Cells"
  • 119. Conrotto P., Yakymovych I., Yakymovych M.Souchelnytskyi S., J. Proteome Res., 6, 287 - 297 (2007), "Interactome of Transforming Growth Factor-beta Type I Receptor (T beta RI): Inhibition of TGF beta Signaling by Epac1"
  • 120. Ster J., De Bock F., Guerineau N. C., Janossy A., Barrere-Lemaire S., Bos J. L., Bockaert J.Fagni L., Proc. Natl. Acad. Sci. U.S.A., 104, 2519 - 2524 (2007), "Exchange Protein Activated by cAMP (Epac) Mediates cAMP Activation of p38 MAPK and Modulation of Ca2+-dependent K+ Channels in Cerebellar Neurons"
  • 121. Carie A. E.Sebti S. M., Oncogene, 26, 3777 - 3788 (2007), "A Chemical Biology Approach Identifies a beta-2 Adrenergic Receptor Agonist that Causes Human Tumor Regression by Blocking the Raf-1/Mek-1/Erk1/2 Pathway"
  • 122. Schmidt M., Sand C., Jakobs K. H., Michel M. C.Weernink P. A. O., Curr. Opin. Pharmacol., 7, 1 - 8 (2007), "Epac and the Cardiovascular System"
  • 123. Doyle M. E.Egan J. M., Pharmacol. Ther., 113, 546 - 593 (2007), "Mechanisms of Action of Glucagon-like Peptide 1 in the Pancreas"
  • 124. Gerdin M. J.Eiden L. E., Science, 382, 15 - 0 (2007), "Regulation of PC12 Cell Differentiation by cAMP Signaling to ERK Independent of PKA: Do all the Connections Add up?"
  • 125. Yokoyama U., Patel H. H., Swaney J. S., Roth D. M.Insel P. A., FASEB J., 21, 996 - 996 (2007), "cAMP Promotes Migration of Cardiac Fibroblasts via Epac and Attenuates their Transformation to Myofibroblasts via PKA"
  • 126. Ulucan C., Wang X., Baljinnyam E.Ishikawa Y., FASEB. J., 21, 1152 - 1152 (2007), "Developmental Changes in Epac Gene Expression in Mice"
  • 127. Pereira L., Metrich M., Fernandez-Velasco M., Lucas A., Leroy J., Perrier R., Morel E., Fischmeister R., Richard S., Benitah J.-P., Lezoualc'h F.Gomez A. M., J. Physiol., 583, 685 - 694 (2007), "The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes"
  • 128. Usynin I., Klotz C.Frevert U., Cell Microbiol., 9, 2610 - 2628 (2007), "Malaria Circumsporozoite Protein Inhibits the Respiratory Burst in Kupffer Cells"
  • 129. Murtazina R., Kovbasnjuk O., Zachos N. C., Li X., Chen Y., Hubbard A., Hogema B. M., Steplock D., Seidler U., Hoque K. M., Tse C. M., De Jonge H. R., Weinmann E. J.Donowitz M., J. Biol. Chem., 282, 25141 - 25151 (2007), "Tissue Specific Regulation of Sodium-Proton Exchanger Isoform 3 (NHE3) Activity in Na/H Exchanger Regulatory Factor 1 (NHERF1) Null Mice: cAMP Inhibition is Differentially Dependent on NHERF1 and Exchange Protein Directly Activated by cAMP (EPAC)Ileum Versus Proximal Tubule"
  • 130. Dremier S., Milenkovic M., Blancquaert S., Dumont J. E., Doeskeland S. O., Maenhaut C.Roger P. R., Endocrinol., 148, 4612 - 4622 (2007), "Cyclic AMP-dependent Protein Kinases, but not Epac, Mediate TSH/cyclic AMP-dependent Regulation of Thyroid Cells"
  • 131. Hatakeyama H., Takahashi N., Kishimoto T., Nemoto T.Kasai H., J. Physiol., 582, 1087 - 1098 (2007), "Two cAMP-dependent Pathways Differentially Regulate Exocytosis of Large Dense-core and Small Vesicles in Mice Beta Cells"
  • 132. Bers D. M., J. Physiol., 583, 685 - 694 (2007), "Going to cAMP Just Got More Complicated"
  • 133. Wayne C. M., Fan H.-F., Cheng X.Richards J. S., Mol. Endocrinol., 21, 1940 - 1957 (2007), "FSH-induces Multiple Signaling Cascades: Evidence that Activation of SRC, RAS and the EGF Receptor are Critical for Granulosa Cell Differentiation"
  • 134. Shibasaki T., Takahashi H., Miki M., Sunaga Y., Matsumura K., Yamanaka M., Zhang C., Tamamoto A., Satoh T., Miyazaki J.-I.Seino S., PNAS, 104, 19333 - 19338 (2007), "Essential Role of Epac2/Rap1 Signaling in Regulation of Insulin Granule Dynamics by cAMP"
  • 135. Hong J., Doebele R. C., Lingen M. W., Quilliam L. A., Tang W. J.Rosner M. R., J. Biol. Chem., 282, 19781 - 19787 (2007), "Anthrax Edema Toxin Inhibits Endothelial Cell Chemotaxis via Epac and Rap1"
  • 136. Canetti C., Serezani C. H., Atrasz R. G., White E. S., Aronoff D. M.Peters-Golden M., J. Immunol., 179, 8350 - 8356 (2007), "Activation of Phosphatase and Tensin Homolog on Chromosome 10 Mediates the Inhibition of Fc{gamma}R Phagocytosis by Prostaglandin E2 in Alevolar Macrophages"
  • 137. Glading A., Han J., Stockton R. A.Ginsberg M. H., J. Cell. Biol., 179, 247 - 254 (2007), "KRIT-1/CCM1 is a Rap1 Effector that Regulates Endothelial Cell Cell Junctions"
  • 138. Kassel K. M., Wyatt T. A., Panettieri R. A.Toews M., Am. J. Physiol. Lung Cell. Mol. Physiol., 294, 131 - 138 (2007), "Inhibition of Human Airway Smooth Muscle Cell Proliferation by {beta}2-adrenergic Receptors and cAMP is PKA-independent: Evidence for Epac Involvement"
  • 139. Chepurny O. G.Holz G. G., J. Biomol. Screen, 12, 740 - 746 (2007), "A Novel Cyclic Adenosine Monophosphate Responsive Luciferase Reporter Incorporating a Nonpalindromic Cyclic Adenosine Monophosphate Response Element Provides Optimal Performance for Use in G Protein Coupled Drug Discovery Efforts"
  • 140. Kooijman R., Gerlo S.Verdood P., Patent WO 2007/006544, 0, 0 - 0 (2007), "Cyclic Adenosine Monophosphate Compounds for the Treatment of Immune-Related Disorders"
  • 141. Bos J. L., Trends Biochem. Sci., 31, 680 - 686 (2006), "Epac Proteins: Multi-purpose cAMP Targets"
  • 142. Hashiguchi H., Nakazaki M., Koriyama N., Fukudome M., Aso K.Tei C., Diabetes Metab. Res. Rev., 22, 64 - 71 (2006), "Cyclic AMP/cAMP-GEF Pathway Amplifies Insulin Exocytosis Induced by CA(2+) and ATP in Rat Islet Beta-cells"
  • 143. Zmuda-Trzebiatowska E., Oknianska A., Manganiello V. C.Degerman E., Cell. Signal., 18, 382 - 390 (2006), "Role of PDE3B in Insulin-induced Glucose Uptake, GLUT-4 Translocation and Lipogenesis in Primary Rat Adipocytes"
  • 144. Borland G., Gupta M., Magiera M. M., Rundell C. J., Fuld S.Yarwood S. J., Mol. Pharmacol., 69, 374 - 384 (2006), "MAP1B-LC1 Enhances Activation of Rap1 by Exchange Protein Activated by Cyclic AMP (EPAC) but not Intracellular Targeting"
  • 145. Gambaryan S., Butt E., Tas P., Smolenski A., Allolio B.Walter U., Am. J. Physiol. Endocrinol. Metab. E, 290, 423 - 433 (2006), "Regulation of Aldosterone Production from Zona Glomerulosa Cells by Ang II and cAMP: Evidence for PKA Independent Activation of CaMK by cAMP"
  • 146. Cheung U., Atwood H. L.Zucker R. S., J. Neurobiol., 66, 273 - 280 (2006), "Presynaptic Effectors Contributing to cAMP-induced Synaptic Potentation in Drosophila"
  • 147. Gerlo S., Verdood P., Hooghe-Peters E. L.Kooijman R., Cell. Mol. Life Sci., 63, 92 - 99 (2006), "Multiple cAMP-induced Signaling Cascades Regulate Prolactin Expression in T Cells"
  • 148. Makranz C., Cohen G., Reichert F., Kodama T.Rotshenker S., Glia., 53, 441 - 448 (2006), "cAMP Cascade (PKA, Epac, Adenylyl Cyclase, Gi, and Phosphodiesterases) Regulates Myelin Phagocytosis Mediated by Complement Receptor-3 and Scavenger Receptor-AI/II in Microglia amd Macrophages"
  • 149. Huang C. C.Hsu K. S., Mol. Pharmacol., 69, 846 - 856 (2006), "Presynaptic Mechanism Underlying cAMP-induced Synaptic Potentation in Medial Prefrontal Cortex Pyramidal Neurons"
  • 150. Honegger K. J., Capuano P., Winter C., Bacic D., Stange G., Wagner C. A., Biber J., Murer H.Hernando N., Proc. Natl. Acad. Sci., 103, 803 - 808 (2006), "Regulation of Sodium-proton Exchanger Isoform 3 (NHE3) by PKA and Exchange Protein Directly Activated by cAMP (EPAC)"
  • 151. Traver S., Marien M., Martin E., Hirsch E. C.Michel P. P., Mol. Pharmacol., 70, 30 - 40 (2006), "The Phenotypic Differentiationof Locus Coeruleus Noradrenergic Neurons Mediated by BDNF is Enhanced by Corticotropin Releasing Factor Through the Activation of a cAMP-dependent Signaling Pathway"
  • 152. Aromataris E. C., Roberts M. L., Barritt G. J.Rychkov G. Y., J. Physiol., 573, 611 - 625 (2006), "Glucagon Activates Ca2+ and Cl-channels in Rat Hepatocytes"
  • 153. Yin F., Wang Y. Y., Du J. H., Li C., Lu Z. Z., Han C.Zhang Y. Y., J. Mol. Cell. Cardiol., 40, 384 - 393 (2006), "Noncanonical cAMP Pathway and p38 MAPK Mediate Beta (2)-adrenergic Receptor-induced IL-6 Production in Neonatal Mouse Cardiac Fibroblasts"
  • 154. Wang Z., Dillon T. J., Pokala V., Mishra S., Labudda K., Hunter B.Swennen E. L. R., Mol. Cell. Biol., 26, 2130 - 2145 (2006), "Rap1-Mediated Activation of Extracellular Signal-Regulated Kinases by Cyclic AMP is Dependent on the Mode of Rap1 Activation"
  • 155. Dao K. K., Teigen K., Kopperud R. K., Hodneland E., Schwede F., Christensen A. E., Martinez A.Doeskeland S. O., J. Biol. Chem., 281, 21500 - 21511 (2006), "Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition"
  • 156. Gonzalez-Iglesias A. E., Jiang Y., Tomic M., Kretschmannova K., Andric S. A., Zemkova H.Stojilkovic S. S., Mol. Endocrinol., 20, 2231 - 2246 (2006), "Dependence of Electrical Activity and Calcium Influx-controlled Prolactin Release on Adenylyl Cyclase Signaling Pathway in Pituitary Lactotrophs"
  • 157. Yip K. P., Am. J. Physiol. Renal. Physiol., 291, 882 - 890 (2006), "Epac Mediated Ca2+mobilization and Exocytosis in Inner Medullary Collecting Duct"
  • 158. De Jesus M. L., Stope M. B., Oude Weernink P. A., Mahlke Y., Börgermann C., Ananba V. N., Rimmbach C., Rosskopf D., Michel M. C., Jakobs K. H.Schmidt M., J. Biol. Chem. 21837 21847, 281, 21837 - 21847 (2006), "Cyclic-AMP-dependent and Epac-mediated Activation of R-Ras by G Protein-coupled Receptors Leads to Phospholipase D Stimulation"
  • 159. Lotfi S., Li Z., Sun J., Zuo Y., Lamm P. P., Kang Y., Rahimi M., Islam D., Wang P., Gaisano H. Y.Jin T., Endocrinology, 147, 3727 - 3736 (2006), "Role of Excange Protein Directly Activated by cyclic Adenosine 5'-monophosphate (Epac) Pathway in Regulating Proglucagon Gene Expression in Intestinal Endocrine L Cells"
  • 160. Hucho T. B., Dina O. A., Kuhn J.Levine J. D., Eur. J. Neurosci., 24, 527 - 534 (2006), "Estrogen Controls PKCepsilon-dependent Mechanical Hyperalgesia Through Direct Action on Nociceptive Neurons"
  • 161. Hatakeyama H., Kishimoto T., Nemoto T., Kasai H.Takahashi N., J. Physiol., 570, 271 - 282 (2006), "Rapid Glucose Sensing by Protein Kinase A for Insulin Exocytosis in Mouse Pancreatic Islets"
  • 162. Meves H., Curr. Neuropharmacol., 4, 41 - 57 (2006), "The Action of Prostaglandins in Ion Channels"
  • 163. Sands W. A., Woolson H. D., Milne G. R., Rutherford C.Palmer T. M., Mol. Cell. Biol., 26, 6333 - 6346 (2006), "Exchange Protein Activated by cyclic AMP(Epac)-mediated Induction of Suppressor of Cytokine Signaling 3 (SOCS-3) in Vascular Endothelial Cells"
  • 164. Gao L., Feng Y. F., Bowers R., Becker-Hapak M., Gardner J., Council L., Linette G., Zhao H. B.Cornelius L. A., Cancer Res., 66, 7880 - 7888 (2006), "RAS-associated Protein-1 Regulates Extracellular Signal-regulated Kinase Activation and Migration in Melanoma Cells: Two Processes Important to Melanoma Tumorigenesis and Metastasis"
  • 165. Shi G.-X., Rehmann H.Andres D. A., Mol. Cell. Biol., 26, 9136 - 9147 (2006), "A Novel cAMP-dependent Epac-Rit Signaling Pathway Contributes to PACAP38-mediated Neuronal Differentiation"
  • 166. McQuaid T. S., Saleh M. C., Joseph J. W., Gyulkhandanyan A., Manning-Fox J. E., MacLellan J. D., Wheeler M. B.Chan C. B., J. Endocrinol., 190, 669 - 680 (2006), "cAMP-mediated Signaling Normalizes Glucose-stimulated Insulin Secretion in Uncoupling Protein-2 Overexpressing {beta}-cells"
  • 167. Zhao C. N., Lai J. S., Warsh J. J.Li P. P., J. Neurosci. Res., 84, 389 - 397 (2006), "G alpha(s) Sensitizes Human SH-SY5Y Cells to Apoptosis Independently of the Protein Kinase A Pathway"
  • 168. Kang G., Chepurny O. G., Malester B., Rindler M. J., Rehmann H., Bos J. L., Schwede F., Coetzee W. A.Holz G. G., J. Physiol.-London, 573, 595 - 609 (2006), "cAMP Sensor Epac as a Determinant of ATP-sensitive Potassium Channel Activity in Human Pancreatic Beta Cells and Rat INS-1 Cells"
  • 169. Gambaryan S., Butt E., Tas P., Smolenski A., Allolio B.Walter U., Amer. J. Physiol.-Endocrinol. Met., 290, 423 - 433 (2006), "Regulation of Aldosterone Production From Zona Glomerulosa Cells by ANG II and cAMP: Evidence for PKA-independent Activation of CaMK by cAMP"
  • 170. Branham M. A. T., Mayorga L. S.Tomes C. N., J. Biol. Chem., 281, 8656 - 8666 (2006), "Calcium-induced Acrosomal Exocytosis Requires cAMP Acting Through a Protein Kinase A-independent, Epac-mediated Pathway"
  • 171. Hashiguchi H., Nakazaki M., Koriyama N., Fukudome M., Aso K.Tei C., Diabetes Metab. Res. Rev., 22, 64 - 71 (2006), "Cyclic AMP/cAMP-GEF Pathway Amplifies Insulin Exocytosis Induced by Ca2+ and ATP in Rat Islet Beta-cells"
  • 172. Liu G. H., Jacobo S. M. P., Hilliard N.Hockerman G. H., J. Pharmacol. Exp. Ther., 318, 152 - 160 (2006), "Differential Modulation of Ca(v)1.2 and Ca(v)1.3-Mediated Glucose-Stimulated Insulin Secretion by cAMP in INS-1 Cells: Distinct Roles for Exchange Protein Directly Activated by cAMP 2 (Epac2) and Protein Kinase A"
  • 173. Miura Y.Matsui H., Toxicol. Appl. Pharmacol., 216, 363 - 372 (2006), "Triphenyltin Impairs a Protein Kinase A (PKA)-dependent Increase of Cytosolic Na(+) and Ca(2+) and PKA-independent Increase of Cytosolic Ca(2+) Associated with Insulin Secretion in Hamster Pancreatic Beta-cells"
  • 174. Aronoff D. M., Carstens J. K., Chen G. H., Toews G. B.Peters-Golden M., J. Interferon Cytokine Res., 26, 827 - 833 (2006), "Differences Between Macrophages and Dentritic Cells in the Cyclic AMP-Dependent Regulation of Lipopolysaccaride-Induced Cytokine and Chemokine Synthesis"
  • 175. Holz G. G., Kang G., Harbeck M., Roe M. W.Chepurny O. G., J. Physiol.- London, 577, 5 - 15 (2006), "Cell Physiology of cAMP Sensor Epac"
  • 176. Bryn T., Mahic M., Enserink J. M., Schwede F., Aandahl E. M.Tasken K., J. Immunol., 176, 7361 - 7370 (2006), "The cyclic AMP-Epac1-Rap1 Pathway is Dissociated from Regulation of Effector Functions in Monocytes but Acquires Immunoregulatory Function in Mature Macrophages"
  • 177. Laxman S., Riechers A., Sadilek M., Schwede F.Beavo J. A., PNAS, 103, 19194 - 19199 (2006), "Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-like Forms"
  • 178. Lorenowicz M. J., van Gils J., de Boer M., Hordijk P. L.Fernandez-Borja M., J. Leukoc. Biol., 80, 1542 - 1552 (2006), "Epac1-Rap1 Signaling Regulates Monocyte Adhesion and Chemotaxis"
  • 179. Kiermayer S., Biondi R. M., Imig J., Plotz G., Haupenthal J., Zeuzem S.Piiper A., Mol. Biol. Cell., 16, 5639 - 5648 (2005), "Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 Cells"
  • 180. Cullereì X., Shawì S. K., Andersson L., Hirahashi J., Luscinskas F. W.Mayadas T. N., Blood, 105, 1950 - 1955 (2005), "Regulation of Vascular Endothelial Barrier Function by Epac, a cAMP Activated Exchange Factor for Rap GTPase"
  • 181. Basoni C., Nobles M., Grimshaw A., Desgranges C., Davies D., Peretti M., Kramer I. M.Genot E., FASEB J., 19, 1 - 25 (2005), "Inhibitory Control of TGF-beta1 on the Activation of Rap1, CD 11b, and Transendothelial Migration of Leukocytes"
  • 182. Gupta M.Yarwood S. J., J. Biol. Chem., 280, 8109 - 8116 (2005), "MAP1A Light Chain (LC) 2 Interacts with Exchange Protein Activated by cyclic AMP 1 (EPAC1) to Enhance Rap1 GTPase Activity and Cell Adhesion"
  • 183. Robert S., Maillet M., Morel E., Launay J.-M., Fischmeister R., Mercken L.Lezoualc'h F., FEBS Lett., 579, 1136 - 1142 (2005), "Regulation of the Amyloid Precursor Protein Ectodomain sheeding by the 5-HT (4) Receptor and Epac"
  • 184. Aronoff D. M., Canetti C., Serezani C. H., Luo M.Peters-Golden M., J. Immunology, 174, 595 - 599 (2005), "Cutting Edge: Macrophage Inhibition by cyclic AMP (cAMP): Differential Roles of Protein Kinase A and Exchange Protein Directly Activated by cAMP-1"
  • 185. Zhong N.Zucker R. S., J. Neurosci., 25, 208 - 214 (2005), "cAMP Acts on Exchange Protein Activated by cAMP/cAMP-regulated Guanine Nucleotide Exchange Protein to Regulate Transmitter Release at the Crayfish Neuromuscular Junction"
  • 186. Murphy M. M., Zayed M. A., Evans A., Parker C. E., Ataga K. I., Telen M. J.Parise L. V., Blood, 105, 3322 - 3329 (2005), "Role of Rap1 in Promoting Sickle Red Blood Cell Adhesion to Laminin via BCAM/LU"
  • 187. Johnson-Farley N. N., Kertesy S. B., Dubyak G. R.Cowen D. S., J. Neurochem., 92, 72 - 82 (2005), "Enhanced Activation of Akt and Extracellular-regulated Kinase Pathways by Simultaneous Occupancy of Gq-coupled 5-HT2A Receptors and Gs-coupled 5-HT7A Receptors in PC12 Cells"
  • 188. Fukuhara S., Sakurai A., Sano H., Yamagishi A., Somekawa S., Takakura N., Saito Y., Kangawa K.Mochizuki N., Mol. Cell. Biol., 25, 136 - 146 (2005), "Cyclic AMP Potentiates Vascular Endothelial Cadherin-mediated Cell-cell Contact to Enhance Endothelial Barrier Function Through an Epac-Rap 1 Signaling Pathway"
  • 189. Kang G., Chepurny O. G., Rindler M. J., Collis L., Chepurny Z., Li W.-H., Harbeck M., Roe M. W.Holz G. G., J. Physiol., 566, 173 - 188 (2005), "A cAMP and Ca2+ Coincidence Detector in Support of Ca2+-induced Ca2+ Release (CICR) in Pancreatic Beta Cells"
  • 190. Brennesvik E. O., Ktori C., Ruzzin J., Jebens E., Shepherd P. R.Jensen J., Cell. Sign., 17, 1551 - 1559 (2005), "Adrenaline Potentiates Insulin-stimulated PKB Activation via cAMP and Epac: Implications for Cross Talk Between Insulin and Adrenaline"
  • 191. Fuld S., Borland G.Yarwood S. J., Exp. Cell Res., 309, 161 - 173 (2005), "Elevation of cyclic AMP in Jurkat T-cells Provokes Distinct Transcriptional Responses Through the Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP (EPAC) Pathways"
  • 192. Moon E. Y., Oh S. Y., Han G. H., Lee C. S.Park S. K., J. Neurosci. Res., 81, 38 - 44 (2005), "Epac1-mediated Rap1 Activation is Not Required for the Production of Nitric Oxide in BV2, Murine Microglial Cells"
  • 193. Sedej S., Rose T.Rupnik M., J. Physiol., 567, 799 - 813 (2005), "cAMP Increases Ca2+-dependent Exocytosis Through Both PKA and Epac2 in Mouse Melantrophs from Pituitary Tissue Slices"
  • 194. Zhang Z., Rehmann H., Price L. S., Riedl J.Bos J. L., J. Biol. Chem., 280, 33200 - 33205 (2005), "AF6 Negatively Regulates Rap1-induced Cell Adhesion"
  • 195. Kooistra M. R. H., Corada M., Dejana E.Bos J. L., FEBS Lett., 579, 4966 - 4972 (2005), "Epac1 Regulates Integrity of Endothelial Cell Junctions Through VE-cadherin"
  • 196. Hucho T. B., Dina O. A.Levine J. D., J. Neurosci., 25, 6119 - 6126 (2005), "Epac Mediates a cAMP-to-PKC Signaling in Inflammatory Pain: An Isolectin B4(+) Neuron-specific Mechanism"
  • 197. Gerlo S., Verdood P., Hooghe-Peters E. L.Kooijman R., Cell Signal, 17, 901 - 909 (2005), "Multiple, PKA-dependent and PKA-independent, Signals are Involved in cAMP-induced PRL Expression in the Eosinophilic Cell Line Eol-1"
  • 198. Somekawa S., Fukuhara S., Nakaoka Y., Fujita H., Saito Y.Mochizuki N., Circ. Res., 97, 655 - 662 (2005), "Enhanced Functional Gap Junction Neoformation by Protein Kinase A-dependent and Epac-dependent Signals Downstream of cAMP in Cardiac Myocytes"
  • 199. Hong J., Beeler J., Zhukovskaya N. L., He W., Tang W. J.Rosner M. R., Biochem. Biophys. Res. Commun., 335, 850 - 857 (2005), "Anthrax Edema Factor Potency Depends on Mode of Cell Entry"
  • 200. Dodge-Kafka K. L., Soughayer J., Pare G. C., Carlisle Michel J. J., Langeberg L. K., Kapiloff M. S.Scott J. D., Nature, 437, 574 - 578 (2005), "The Protein Kinase A Anchoring Protein mAKAP Coordinates Two Integrated cAMP Effector Pathways"
  • 201. Oynebraten I., Barois N., Hagelsteen K., Johansen F. E., Bakke O.Haraldsen G., J. Immunol., 175, 5358 - 5369 (2005), "Characterization of a Novel Chemokine-containing Storage Granule in Enthothelial Cells: Evidence for Preferential Exocytosis Mediated by Protein Kinase A and Diacylglycerol"
  • 202. Li Y., Asuri S., Rebhun J. F., Castro A. F., Paranavitana N. C.Quilliam L. A., J. Biol. Chem., 281, 2506 - 2514 (2005), "The Rap1 Guanine Nucleotide Exchange Factor, Epac2, Couples cyclic AMP and RAS Signals at the Plasma Membrane"
  • 203. Ma X. S., Zhang Y., Gromada J., Sewing S., Berggren P. O., Buschard K., Salehi A., Vikman J., Rorsman P.Eliasson L., Mol. Endocrinol., 19, 198 - 212 (2005), "Glucagon Stimulates Exocytosis in Mouse and Rat Pancreatic Alpha-cells by Binding to Glucagon Receptors"
  • 204. Morel E., Marcantoni A., Gastineau M., Birkedal R., Rochais F., Garnier A., Lompre A. M., Vandecasteele G.Lezoualc'h F., Circ. Res., 97, 1296 - 1304 (2005), "cAMP-binding Protein Epac Induces Cardiomyocyte Hypertrophy"
  • 205. Helms M. N., Chen X. J., Ramosevac S., Eaton D. C.Jain L., Am. J. Physiol. Lung Cell Mol. Physiol., 290, 0 - 0 (2005), "Dopamine Regulation of Amiloride-sensitive Sodium Channels in Lung Cells"
  • 206. Griffin R. S., J. Neurosci., 25, 8113 - 8114 (2005), "An Epac-dependent Pain Pathway"
  • 207. Rehmann H., Methods Enzymol., 407, 159 - 173 (2005), "Characterization of the Activation of the Rap-specific Exchange Factor Epac by Cyclic Nucleotides"
  • 208. Murphy M. M., Zayed M. A., Evans A., Parker C. E., Ataga K. I., Telen M. J.Parise L. V., Blood, 105, 3322 - 3329 (2005), "Role of Rap1 in Promoting Sickle Red Blood Cell Adhesion to Laminin Via BCAM/LU"
  • 209. Kamrava M., Simpkins F., Alejandro E., Michener C., Meltzer E.Kohn E. C., Oncogene, 24, 7084 - 7093 (2005), "Lysophosphatidic Acid and Endothelin-induced Proliferation of Ovarian Cancer Cell Lines is Mitigated by Neutralization of Granulin-epithelin Precursor (GEP), a Prosurvival Factor for Ovarian Cancer"
  • 210. Antunes T. T., Gagnon A. M., Bell A.Sorisky A., Obesity Research, 13, 2066 - 2071 (2005), "Thyroid-Stimulating Hormone Stimulates Interleukin-6 Release From 3T3-L1 Adipocytes Through a cAMP-Protein Kinase A Pathway"
  • 211. Seldon P. M., Meja K. K.Giembycs M. A., Pulmon. Pharmacol. Therapeut., 18, 277 - 284 (2005), "Rolipram, salbutamol and prostaglandin E2 suppress TNFa release from human monocytes by activating Type II cAMP-dependent protein kinase"
  • 212. Kwon G., Pappan K. L., Marshall C. A., Schaffer J. E.McDaniel M. L., J. Biol. Chem., 279, 8938 - 8945 (2004), "Cyclic AMP Dose-dependently Prevents Palmitate-induced Apoptosis by Both PKA- and cAMP-GEF-dependent Pathways in Beta-cells"
  • 213. Tiwari S., Felekkis K., Moon E. Y., Flies A., Sherr D. H.Lerner A., Blood, 103, 2661 - 2667 (2004), "Among Circulating Hematopoietic Cells, B-CLL Uniquely Expresses Functional EPAC1 but EPAC1-mediated Rap1 Activation does not Account for PDE4 Inhibitor-induced Apoptosis"
  • 214. Holz G. G., Diabetes, 53, 5 - 13 (2004), "Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor -Mediated Signal Transduction in the Pancreatic Beta-Cell"
  • 215. Ivins J. K., Parry M. K.Long D. A., J. Neurosci., 5, 1212 - 216 (2004), "A Novel cAMP-dependent Pathway Activates Neuronal Integrin Function in Retinal Neurons"
  • 216. Cullen K., McCool J., Anwer M. S.Webster C. R., Am. J. Physiol. Gastrointest. Liver Physiol. G, 287, 334 - 343 (2004), "Activation of cAMP-Guanine Exchange Factor (cAMP-GEF) Confers Protein Kinase A Independent Protection from Hepatocyte Apoptosis"
  • 217. Fleming Y. M., Frame M. C.Houslay M. D., J. Cell. Sci., 117, 2377 - 2388 (2004), "PDE4-regulated cAMP Degradation Controls the Assembly of Integrin-dependent Actin Adhesion Structures and REF52 Cell Migration"
  • 218. Vom Dorp F., Sari A. Y., Sanders H., Keiper M., Oude Weernink P. A., Jakobs K. H.Schmidt M., Cell Signal., 16, 921 - 928 (2004), "Inhibition of Phospholipase C-epsilon by G(i)-coupled Receptors"
  • 219. Rondaij M. G., Sellink E., Gijzen K. A., Ten Klooster J. P., Hordijk P. L., Van Mourik J. A.Voorberg J., Arterioscler. Thromb. Vasc. Biol., 24, 1315 - 1320 (2004), "Small GTP-Binding Protein Ral is Involved in cAMP-mediated Release of von Willebrand Factor From Endothelial Cells"
  • 220. Novara M., Baldelli P., Cavallari D., Carabelli V., Giancippoli A.Carbone E., J. Physiol., 558, 433 - 449 (2004), "Exposure to cAMP and (beta)-adrenergic Stimulation Recruits CaV3 T-type Channels in Rat Chromaffin Cells Through Epac cAMP-receptor Proteins"
  • 221. Zhong N.Zucker R. S., J. Neurosci., 24, 4205 - 4212 (2004), "Roles of Ca2+, Hyperpolarization and Cyclic Nucleotide-activated Channel Activation, and Actin in Temporal Synaptic Tagging"
  • 222. Zhong N., Beaumont V.Zucker R. S., J. Neurophysiol., 92, 644 - 647 (2004), "Calcium Influx Through HCN Channels Does not Conribute to cAMP-enhanced Transmission"
  • 223. Kaneko M.Takahashi T., J. Neurosci., 24, 5202 - 5208 (2004), "Presynaptic Mechanism Underlying cAMP-dependent Synaptic Potentiation"
  • 224. Mahic M., Bryn T., Enserink J. M., Schwede F., Aandahl E. M.Tasken K., Poster #THP019 Montreal, 12, 0 - 0 (2004), "Modulation of Monocyte Activation by Cyclic AMP is Mainly Mediated Through Protein Kinase A"
  • 225. Selheim F., Krakstad C., Christensen A.-E., Hagland H., Schwede F., Genieser H.-G.Doeskeland S. O., Poster # THP017 Montreal, 12, 0 - 0 (2004), "The cAMP Receptor Epac Has a Permissive Role for cAMP-dependent Protein Kinase Action to Protect PC-12 Pheochromocytoma Cells Against Stress-induced Apoptosis and Induce Neuronal Differentiation"
  • 226. Nishihara H., Hwang M., Kizaka-Kondoh S., Eckmann L.Insel P. A., J. Biol. Chem., 279, 26176 - 26183 (2004), "Cyclic AMP Promotes cAMP-responsive Element-binding Protein-dependent Induction of Cellular Inhibitor of Apoptosis Protein-2 and Suppresses Apoptosis of Colon Cancer Cells through ERK1/2 and p38 MAPK"
  • 227. Chen C., Koh A. J., Datta N. S., Zhang J., Keller E. T., Xiao G., Franceschi R. T., D'Silva N. J.McCauley L. K., J. Biol. Chem., 279, 29121 - 29129 (2004), "Impact of the Mitogen-activated Protein Kinase Pathway on Parathyroid Hormone-related Protein Actions in Osteoblasts"
  • 228. Dyachok O.Gylfe E., J. Biol. Chem., 279, 45455 - 45461 (2004), "Ca2+-induced Ca2+ Release via Inositol 1,4,5-triphosphate Receptors is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic Beta-cells"
  • 229. Zhang L.Insel P. A., J. Biol. Chem., 279, 20858 - 20865 (2004), "The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells"
  • 230. Keiper M., Stope M. B., Szatkowski D., Böhm A., Tysack K., Vom Dorp F., Saur O., Weernink P. A. O., Evellin S., Jakobs K. H.Schmidt M., J. Biol. Chem., 279, 46497 - 46508 (2004), "Epac- and Ca2+-controlled Activation of Ras and Extracellular Signal-regulated Kinases by G(s)-coupled Receptors"
  • 231. Krakstad C., Chua N. H.Doeskeland S. O., J. Leukoc. Biol., 76, 641 - 647 (2004), "cAMP Protects Neutrophils against TNF-Alpha-induced Apoptosis by Activation of cAMP-dependent Protein Kinase, Independently of Exchange Protein Directly Activated by cAMP (EPAC)"
  • 232. Johansson C. C., Yndestad A., Enserink J. M., Ree A. H., Aukrust P.Tasken K., Endocrinology, 145, 51777 - 51784 (2004), "The EGF-Like Growth Factor Amphiregulin is Strongly Induced by the cAMP Pathway in Various Cell Types"
  • 233. Nguyen G. H., French R.Radhakrishna H., Cell Signal., 16, 1141 - 1151 (2004), "Protein Kinase A Inhibits Lysophosphatidic Acid Induction of Serum Response Factor via Alterations in the Actin Cytoskeleton"
  • 234. Shimomura H., Imai A.Nashida T., Arch. Biochem. Biophys., 431, 124 - 128 (2004), "Evidence for the Involvement of cAMP-GEF (Epac) Pathway in Amylase Release from the Rat Parotid Gland"
  • 235. Jing H., Yen J. H.Ganea D., J. Biol. Chem., 279, 55176 - 55186 (2004), "A Novel Signaling Pathway Mediates the Inhibition of CCL3/4 Expression by PGE2"
  • 236. Ponsioen B., Zhao J., Riedl J., Zwartkruis F., van der Krogt G. N. M., Zaccolo M., Moolenaar W. H., Bos J. L.Jalink K., EMBO Rep., 5, 1176 - 1180 (2004), "Detecting cAMP-induced Epac Activation by Fluorescence Resonance Energy Transfer: Epac as a Novel cAMP Indicator"
  • 237. Dipilato L. M., Cheng X.Zhang J., Proc. Natl. Acad. Sci. USA, 101, 16513 - 6518 (2004), "Fluorescent Indicators of cAMP and Epac Activation Reveal Differential Dynamics of cAMP Signaling within Discrete Subcellular compartments"
  • 238. Chin E. C.Abayasekera D. R. E., J. Endocrinol., 183, 51 - 60 (2004), "Progesterone Secretion by Luteinizing Human Granulosa Cells: a Possible cAMP-dependent but PKA-independent Mechanism Involved in its Regulation"
  • 239. Chen L., Wang P., Andrade C. F., Zhao I. Y., Dube P. E., Brubaker P. L., Liu M.Jin T., FEBS J., 272, 2746 - 2759 (2004), "PKA Independent and Cell Type Specific Activation of the Expression of Caudal Homeobox Gene Cdx-2 by cyclic AMP"
  • 240. McPhee I., Gibson L. C. D., Kewney J., MacKenzie F., Darroch C., Stevens P., Breslin C., McFarlane M.MacKenzie S. J., Patent No. WO 2004/096199 A2, 0, 0 - 0 (2004), "Drug Discovery in Alzheimers Using Cyclic Nucleotide Focused Gene Array"
  • 241. Jensen B. O., Selheim F., Doeskeland S. O., Gear A. R. L.Holmsen H., Blood, 104, 2775 - 2782 (2004), "Protein Kinase A Mediates Inhibition of the Thrombin-Induced Platelet Shape Change by Nitric Oxide"
  • 242. Kang G., Joseph J. W., Chepurny O. G., Monaco M., Wheeler M. B., Bos J. L., Schwede F., Genieser H.-G.Holz G. G., J. Biol. Chem., 278, 8279 - 8285 (2003), "Epac-Selective cAMP Analog 8-pCPT-2'-O-Me-cAMP As A Stimulus For Ca 2+ -Induced Ca 2+ Release And Exocytosis In Pancreatic Beta-Cells"
  • 243. Rangarajan S., Enserink J. M., Kuiperij H. B., de Rooij J., Price L. S., Schwede F.Bos J. L., J. Cell Biol., 160, 487 - 493 (2003), "Cyclic AMP Induces Integrin-mediated Cell Adhesion Through Epac and Rap1 Upon Stimulation of the ß2-Adrenergic Receptor"
  • 244. Rehmann H., Schwede F., Doeskeland S. O., Wittinghofer A.Bos J. L., J. Biol. Chem., 278, 38548 - 38556 (2003), "Ligand-mediated Activation of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac"
  • 245. Enyeart J. A., Danthi S.Enyeart J. J., Mol. Pharmacol., 64, 132 - 142 (2003), "Corticotropin Induces the Expression of TREK-1 mRNA and K+ Current in Adrenocortical Cells"
  • 246. Zeleznik A. J., Saxena D.Little-Ihrig L., Endocrinology, 144, 3985 - 3994 (2003), "Protein Kinase B is Obligatory for Follicle Stimulating Hormone-induced Granulosa Cell Differentiation"
  • 247. Hirakawa T.Ascoli M., Mol. Endocrinol., 17, 2189 - 2200 (2003), "The Lutropin/Choriogonadotropin Receptor (LHR)-induced Phosphorylation of the Extracellular Signal Regulated Kinases (ERKs) in Leydig Cells is Mediated by a Protein Kinase A-dependent Activation of Ras"
  • 248. Sakaba T.Neher E., Nature, 424, 775 - 778 (2003), "Direct Modulation of Synaptic Vesicle Priming by GABA(B) Receptor Activation at a Glutamatergic Synapse"
  • 249. Kopperud R. K., Krakstad C., Selheim F.Doeskeland S. O., FEBS Lett., 546, 121 - 126 (2003), "cAMP Effector Mechanisms. Novel Twists for an 'Old' Signaling System"
  • 250. Bos J. L., Nature Rev. Mol. Cell Biol., 4, 733 - 738 (2003), "Epac: A New cAMP Target and New Avenues in cAMP Research"
  • 251. Christensen A. E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K. K., Martinez A., Maenhaut C., Bos J. L., Genieser H.-G.Doeskeland S. O., J. Biol. Chem., 278, 35394 - 35402 (2003), "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"
  • 252. Eliasson L., Ma X. S., Renström E., Barg S., Berggren P.-O., Galvanovskis J., Gromada J., Jing X. J., Lundquist I., Salehi A., Sewing S.Rorsman P., J. Gen. Physiol., 121, 181 - 197 (2003), "SUR1 Regulates PKA-Independent cAMP-Induced Granule Priming in Mouse Pancreatic B-Cells"
  • 253. Maillet M., Robert S. J., Cacquevel M., Gastineau M., Vivien D., Bertoglio J., Zugaza J. L., Fischmeister R.Lezoualc'h F., Nat. Cell Biol., 5, 633 - 639 (2003), "Crosstalk between Rap1 and Rac Regulates Secretion of sAPP Alpha"
  • 254. Chua N. H., Ph.D.Thesis Dept. of Anatomy and Cell Biology, 0, 0 - 0 (2003), "Novel Aspects of cAMP Signaling - Cyclic AMP Analogs as Tools to Elucidate the Rules of cAMP-Kinase and Epac"
  • 255. Christensen A. E.Doeskeland S. O., Handbook of Cell Signaling Academic Press/Elsevier Science San Diego CA, 2, 549 - 554 (2003), "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling"
  • 256. Bos J. L., de Bruyn K., Enserink J. M., Kuiperij H. B., Rangarajan S., Rehmann H., Riedl J., de Rooij J., van Mansfeld F.Zwartkruis F. J. T., Biochem. Soc. Trans., 31, 83 - 86 (2003), "The Role of Rap 1 in Integrin-mediated Cell Adhesion"
  • 257. Lin S. L., Johnson-Farley N. N., Lubinsky D. R.Cowen D. S., J. Neurochem., 87, 1076 - 1085 (2003), "Coupling of Neuronal 5-HT7 Receptors to Activation of Extracellular-regulated Kinase through a Protein Kinase A-independent Pathway that can Utilize Epac"
  • 258. Ehses J. A., Casilla V. R., Doty T., Pospisilik J. A., Winter K. D., Demuth H. U., Pederson R. A.McIntosh C. H., Endocrinology, 144, 4433 - 4445 (2003), "Glucose-dependent Insulinotropic Polypeptide Promotes Beta-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-activated Protein Kinase"
  • 259. MacDonald P. E., Xiaolin W., Xia F., El-kholy W., Targonsky E., Tsuhima R. G.Wheeler M. B., J. Biol. Chem., 278, 52446 - 52453 (2003), "Antagonism of Rat Beta-cell Voltage-dependent K+ Currents by Exendin-4 Requires Dual Activation of the cAMP/PKA and PI3 Kinase Signaling Pathways"
  • 260. Miura Y.Matsui H., Am. J. Pysiol.-Endocrinol. Metab., 285, 1001 - 1009 (2003), "Glucagon-like Peptide-1 Induces a cAMP-dependent Increase of [Na+](i) Associated with Insulin Secretion in Pancreatic Beta-cells"
  • 261. Christensen A. E., de Rooij J., Kopperud R. K., Nilsen O. K., Dao K. K., Schwede F., Bos J. L., Genieser H.-G.Doeskeland S. O., Abstract of the 13th Protein Kinase Symposium, 0, 5 - 5 (2002), "Comparison of the cAMP Binding Sites of EPAC-1 and cAMP-Kinase"
  • 262. Enserink J. M., Christensen A. E., de Rooij J., van Triest M., Schwede F., Genieser H.-G., Doeskeland S. O., Blank J. L.Bos J. L., Nature Cell Biol., 4, 901 - 906 (2002), "A Novel Epac-specific cAMP Analogue Demonstrates Independent Regulation of Rap 1 and ERK"
  • 263. Enserink J. M., Abstract of the 13th Protein Kinase Symposium, 0, 9 - 9 (2002), "cAMP-induced Cell Adhesion to Fibronectin is Mediated by Epac and Rap1"
  • 264. Rodriguez P., Snyder S. K., Chiffer R. C.Smith C. L., Manuskript, 0, 0 - 0 (2000), "cAMP Signaling Induces Rapid Dephosphorylation of Histone H3 Independently of Protein Kinase A and Epac"

Show more