Basket (0 Items) - Amount: 0.00$8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose ( Sp-8-AEA-cAMPS-Agarose )
Hydrolysis-resistant Sp-cAMPS immobilized on agarose
The protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylamino spacer attached to position 8 of the ligand. Free Sp-cAMPS is only very slowly metabolized by corresponding phosphodiesterases and thus represents an extraordinary stable ligand. In addition, its reduced binding affinity towards protein kinase A compared to cAMP should result in potentially milder desorption conditions in affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. This ligand is offered with a longer spacer (Sp-8-AHA-cAMPS-Agarose, Cat. No. A 013) as well. Detailed technical information available.
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.
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