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Up₄A / Ap₄U

P¹- (5'- Adenosyl)- P⁴- (5'- uridyl)- tetraphosphate ( Up₄A / Ap₄U ), sodium salt
Cat. No.: U 008
CAS No.: [10527-48-7]
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Product Name Price (net) Qty
Cat. No.: U 008-01
Unit: 1 µmol / ~0.8 mg
For other salt forms or analogues please inquire. Up4A is a dinucleoside polyphosphate containing both, a purine as well as a pyrimidine nucleobase moiety. Purinoceptor agonist and potent endothelial-derived contracting factor. Detailed technical information and references available. Reference: Jankowski et al., Nature Medicine, 11, 223 - 227 (2005).
Cat. No. U 008
CAS number [10527-48-7]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₉H₂₇N₇O₂₁P₄ (free acid)
Molecular weight [g/mol] 813.4 (free acid)
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 22700
  • 1. Durnin L., Hwang S. J., Kurahashi M., Drumm B. T., Ward S. M., Sasse K. C., Sanders K. M.Mutafova-Yambolieva V. N., Proc. Natl. Acad. Sci. USA, 111, 15821 - 15826 (2014), "Uridine Adenosine Tetraphosphate is a Novel Neurogenic P2Y1 Receptor Activator in the Gut"
  • 2. Linder A. E., Tumbri M., Linder F. F. P., Webb C.Leite R., Vascular Pharmacol., 48, 202 - 207 (2008), "Uridine Adenosine Tetraphoshate Induces Contraction and Relaxation in Rat Aorta"
  • 3. Gui Y., Walsh M. P., Jankowski V., Jankowski J.Zheng X. L., Am. J. Physiol. Lung Cell. Mol. Physiol., 294, 733 - 738 (2008), "Up4A Stimulates Endothelium-independent Contraction of Isolated Rat Pulmonary Artery"
  • 4. Jankowski V., Patzak A., Herget-Rosenthal S., Tran T. N. A., Lai E. Y., Günthner T., Buschmann I., Zidek W.Jankowski J., J. Mol. Med., 86, 333 - 340 (2008), "Uridine Adenosine Tetraphoshate Acts as an Autocrine Hormone Affecting Glomerular Filtration Rate"
  • 5. Bie P., Madsen O.Wolff H., FASEB J. 597.7, 21, 0 - 0 (2007), "Cardiorenal Effects of Infusion of Uridine Adenosine Tetraphosphate (Up4A) to Conscious Rats: Hypertension and Electrolyte Retention"
  • 6. Jankowski V., Meyer A.-A., Schlattmann P., Gui Y., Zheng X.-l., Stamcou I., Radtke K., Tran T. N. A., van der Giet M., Tölle M., Zidek W.Jankowski J., Arterioscler. Thromb. Vasc. Biol., 27, 1776 - 1781 (2007), "Increased Uridine Adenosine Tetraphosphate Concentrations in Plasma of Juvenile Hypertensives"
  • 7. Leite R., Linder F. F. P., Linder E.Webb R. C., FASEB J. A1185, 20, 0 - 0 (2006), "Uridine Adenosine Tetraphosphate-induced Contraction is Modulated by the Endothelium and Involves an Increased Superoxide Formation in DOCA-Salt Hypertension"
  • 8. Jankowski V., Tölle M., Vanholder R., Schönfelder G., van der Giet M., Henning L., Schlüter H., Paul M., Zidek W.Jankowski J., Nature Med., 11, 223 - 227 (2005), "Uridine Adenosine Tetraphosphate: A Novel Endothelium-derived Vasoconstrictive Factor"