For other salt forms or analogues please inquire. Synonym: P1- (5'- Guanosyl)- P4- (5'- adenosyl)- tetraphosphate. Ap4G is a dinucleoside polyphosphate containing two different purine nucleobase moieties and shows vasoactivity. Detailed technical information and references available. References: Schlüter et al., J. Clin. Invest., 101, 682 - 688 (1998); Lewis et al., Br. J. Pharmacol., 129, 124 - 130 (2000); Van der Giet et al., Br. J. Pharmacol., 132, 467 - 474 (2001); Ralevic et al., Br. J. Pharmacol., 134, 1073 - 1083 (2001).
| Cat. No. | A 177 |
| CAS number | [10527-46-5] |
| Purity | > 95% HPLC |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₂₀H₂₈N₁₀O₂₀P₄ (free acid) |
| Molecular weight [g/mol] | 852.4 (free acid) |
| Absorption max [nm] | 255 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 24400 |
- 1. van der Giet M., Westhoff T., Cinkilic O., Jankowski J., Schlüter H., Zidek W.Tepel M., Br. J. Pharmacol., 132, 467 - 474 (2001), "The Critical Role of Adenosine and Guanosine in the Affinity of Dinucleoside Polyphosphates to P(2X)-Receptors in the Isolated Perfused Rat Kidney"
- 2. Ralevic V., Jankowski J.Schlüter H., Br. J. Pharmacol., 134, 1073 - 1083 (2001), "Structure-Activity Relationships of Diadenosine Polyphosphates (Ap(n)As), Adenosine Polyphospho Guanosines (Ap(n)Gs) and Guanosine Polyphospho Guanosines (Gp(n)Gs) at P2 Receptors in the Rat Mesenteric Arterial Bed"
- 3. Lewis C. J., Gitterman D. P., Schlüter H.Evans R. J., Br. J. Pharmacol., 129, 124 - 130 (2000), "Effects of Diadenosine Polyphosphates (Ap(n)As) and Adenosine Polyphospho Guanosines (Ap(n)Gs) on Rat Mesenteric Artery P2X Receptor Ion Channels"
- 4. Schlüter H., Groß I., Bachmann J., Kaufmann R., van der Giet M., Tepel M., Nofer J.-R., Assmann G., Karas M., Jankowski J.Zidek W., J. Clin. Invest., 101, 682 - 688 (1998), "Adenosine(5') Oligophospho-(5') Guanosines and Guanosine(5') Oligophospho-(5') Guanosines in Human Platelets"
