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Alternative structural projections:


8- Bromoadenosine- 3', 5'- monophosphorothioate, acetoxymethyl ester, Sp- isomer ( Sp-8-Br-cAMPS-AM )
Metabolically activatable prodrug form of the PDE-resistant PKA activator Sp-8-Br-cAMPS
Cat. No.: B 029
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: B 029-01
Unit: 1 µmol / ~0.5 mg
Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-8-Br-cAMPS (Cat. No. B 002). Metabolic bioactivation by esterases releases the active analogue, which is trapped inside the cell. Chemical hydrolysis can produce some 8-Br-cAMP as well. Detailed technical information available. Compare: Maronde et al., J. Pineal Res., 31, 183 - 185 (2001). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. B 029
CAS number [pending]
Purity > 97% HPLC for mixture of the axial and equatorial isomer
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₅BrN₅O₇PS
Molecular weight [g/mol] 496.2
Modifications 8-cAMP
Target PKA (cAK) Activator
Absorption max [nm] 264
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Wolter S., Kloth C., Golombek M., Dittmar F., Försterling L.Seifert R., Biochem. Pharmacol., 98, 119 - 131 (2015), "cCMP Causes Caspase-dependent Apotosis in Mouse Lymphoma Cell Lines"