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Alternative structural projections:


2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose ( Sp-2-AEA-cAMPS-Agarose )
PDE-resistant Sp-cAMPS immobilized to agarose
Cat. No.: A 087
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 087-06
Unit: 0.6 ml
Cat. No.: A 087-25
Unit: 2.5 ml
Cat. No.: A 087-60
Unit: 6 ml

The protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylamino spacer attached to position 2 of the ligand. Free Sp-cAMPS is only very slowly metabolized by corresponding phosphodiesterases and thus represents an extraordinary stable ligand. In addition, its reduced binding affinity towards protein kinase A compared to cAMP results in potentially milder desorption conditions in affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. This ligand is offered with a longer spacer (Sp-2-AHA-cAMPS-Agarose, Cat. No. A 069) as well. Detailed technical information available.

Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.


Appearance: Suspension in 30 mM Na2HPO4 buffer (pH 7).

Cat. No. A 087
CAS number [pending]
Appearance Suspension in 30 mM Na₂HPO₄ buffer (pH 7)
Storage temperature 4°C / 39°F
cAMP modified at the exocyclic oxygen axial (Sp-)
Modifications 2-cAMP
  • 1. Lefkimmiatis K., Moyer M. P., Curci S.Hofer A. M., PLoS One, 4, 0 - 0 (2009), "'cAMP sponge': a Buffer for Cyclic Adenosine 3', 5'-monophosphate"