For other salt forms please inquire. 2'-pRib-AMP is the monomeric metabolite of poly(ADP-ribose) (PAR) and can be used to detect and analyse PAR-specific binding properties of poly(ADP-ribose) polymerases (Wang et al. 2018). Recent studies have shown that plant nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain recognise pathogen effectors. The TIR-enabled nicotinamideadenine dinucleotide hydrolase (NADase) activity is used to mediate the immune response. It has been shown that TIR-containing proteins can biocatalyse the production of 2'-pRib-AMP from NAD+ in plants, and it has been postulated that 2'-pRib-AMP may have a second messenger function in TIR signalling of plant immunity (Jia et al. 2022, Huang et al. 2022). References: Wang et al., Methods Mol. Biol., 1813, 65 - 73 (2018); Jia et al., Science, 377:eabq8180 (2022); Huang et al., Science, 377:eabq3297 (2022)
| Cat. No. | P 128 |
| CAS number | [1672716-76-5] |
| Purity | > 95% HPLC |
| Salt form | Sodium |
| Appearance | Solid |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₅H₂₃N₅O₁₄P₂ (free acid) |
| Molecular weight [g/mol] | 559.3 (free acid) |
| Absorption max [nm] | 260 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 15000 |
| UV pH value | 7 |
| Solvent for UV data | Water |
