For other salt forms please inquire. Sp-2',3'-cGMPS and its corresponding Rp-isomer (Rp-2',3'-cGMPS, Cat. No. G 070) are valuable tools for determination of the stereochemical requirements of 2',3'-cGMP binding receptors. Depending on the type of receptor they could behave as agonists or inhibitors of the binding site. Often phosphorothioate-modified nucleotides are more stable against metabolic degradation compared to their sulfur-free parent structures.
According to Eckstein et al. (1972), Rp-2',3'-cGMPS is hydrolyzed by ribonuclease T1 (RNase T1), which converts guanosine 3'-phosphate esters to guanosine 3'-phosphate with guanine 2′,3′-cyclic monophosphate (2′,3′-cGMP) as intermediate, while the Sp-isomer Sp-2',3'-cGMPS resists hydrolysis and acts as a competitive inhibitor for this enzyme. Reference: Eckstein et al., Biochemistry, 11, 3507 - 3512 (1972)
| Cat. No. | G 071 |
| CAS number | [38557-86-7] |
| Purity | > 97% HPLC |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₀H₁₁N₅O₆PS · Na |
| Molecular weight [g/mol] | 383.3 |
| Absorption max [nm] | 252 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 14300 |
| UV pH value | 7 |
| Solvent for UV data | Water |
