For other salt forms please inquire. Biotinylated analogue of the metazoan cyclic dinucleotide second messenger and STING activator c[G(2',5')pA(3',5')p] (aka cGAMP(2'-5') or 2'3'-cGAMP, Cat. No. C 161) in which the biotin label is attached to the 3'-hydroxy group of the guanosine via a 16-atom spacer. Potential tracer in immunoassays, for affinity chromatography or pull-down assays.
c[G(2',5')pA(3',5')p] was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). Detailed technical information available. References for c[G(2',5')pA(3',5')p]: Gao et al., Cell, 153, 1094 - 1107 (2013); Ablasser et al., Nature, 498, 380 - 384 (2013); Zhang et al., Mol. Cell, 51, 226 - 235 (2013); Diner et al., Cell Rep., 3, 1355 - 1361 (2013).
Cat. No. | C 196 |
CAS number | [pending] |
Purity | > 95% HPLC |
Salt form | Sodium |
Storage temperature | -20°C / -4°F |
Molecular formula | C₄₃H₆₃N₁₅O₁₇P₂S (free acid) |
Molecular weight [g/mol] | 1156.1 (free acid) |
Absorption max [nm] | 258 |
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 25050 |