0 Items - $0.00
Categories
A to Z

Alternative structural projections:

c[G(2',5')p-2'-Biotin-16-A(3',5')p]

Cyclic (guanosine- (2' −> 5')- monophosphate- 2'- O- (6- (6- [biotinyl]aminohexanoyl)aminohexylcarbamoyl)adenosine- (3' −> 5')- monophosphate) ( c[G(2',5')p-2'-Biotin-16-A(3',5')p] / c[G(2',5')p-2'-[Biotin]-AHC-A(3',5')p] ), sodium salt

Biotinylated analogue of c[G(2',5')pA(3',5')p] / 2'3'-cGAMP
Cat. No.: C 197
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 197-001
Unit: 0.1 µmol / ~0.1 mg
$337.00

For other salt forms please inquire. Biotinylated analogue of the metazoan cyclic dinucleotide second messenger and STING activator c[G(2',5')pA(3',5')p] (aka cGAMP(2'-5') or 2'3'-cGAMP, Cat. No. C 161) in which the biotin label is attached to the 2'-hydroxy group of the adenosine via a 16-atom spacer. Potential tracer in immunoassays, for affinity chromatography or pull-down assays.

c[G(2',5')pA(3',5')p] was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). Detailed technical information available. References for c[G(2',5')pA(3',5')p]: Gao et al., Cell, 153, 1094 - 1107 (2013); Ablasser et al., Nature, 498, 380 - 384 (2013); Zhang et al., Mol. Cell, 51, 226 - 235 (2013); Diner et al., Cell Rep., 3, 1355 - 1361 (2013).

Cat. No. C 197
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₄₃H₆₃N₁₅O₁₇P₂S (free acid)
Molecular weight [g/mol] 1156.1 (free acid)
Absorption max [nm] 258
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 25050