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Alternative structural projections:

Sp-cAMPS-AM

Adenosine- 3', 5'- monophosphorothioate acetoxymethyl ester, Sp- isomer (Sp-cAMPS-AM)
Metabolically activatable prodrug of the PDE-resistant PKA agonist Sp-cAMPS
Cat. No.: A 035
    
CAS No.: [152218-24-1]
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Product Name Price (net) Qty
Cat. No.: A 035-01
Unit: 1 µmol / ~0.4 mg
$132.00
Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-cAMPS. Metabolic bioactivation by esterases releases the active analogue, which is trapped inside the cell. Chemical hydrolysis can produce some cyclic AMP as well. Detailed technical information available. Reference: Maronde et al., J. Pineal Res., 31, 183 - 185 (2001). Vanhoose et al., J. Neurosci., 26, 1138 - 1145 (2006). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. A 035
CAS number [152218-24-1]
Purity > 97% HPLC for mixture of the axial and equatorial isomer
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₆N₅O₇PS
Molecular weight [g/mol] 417,3
Target PKA (cAK) Activator
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15200
  • 1. Wolter S., Kloth C., Golombek M., Dittmar F., Försterling L.Seifert R., Biochem. Pharmacol., 98, 119 - 131 (2015), "cCMP Causes Caspase-dependent Apotosis in Mouse Lymphoma Cell Lines"
  • 2. Scott S.-P., Shea P. W.Dryer S. E., Biochem., 46, 9417 - 9431 (2007), "Mapping Ligand Interactions with the Hyperpolarization Activated Cyclic Nucleotide Modulated (HCN) Ion Channel Binding Domain Using a Soluble Construct"
  • 3. Vanhoose A. M., Clements J. M.Winder D. G., J. Neurosci., 26, 1138 - 1145 (2006), "Novel Blockade of Protein Kinase A-Mediated Phosphorylation of AMPA Receptors"
  • 4. Christensen A. E.Doeskeland S. O., Handbook of Cell Signaling Academic Press/Elsevier Science San Diego CA, 2, 549 - 554 (2003), "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling"
  • 5. Maronde E., Korf H. W., Niemann P.Genieser H.-G., J. Pineal Res., 31, 183 - 185 (2001), "Direct Comparison of the Potency of Three Novel cAMP Analogs to Induce CREB-Phosphorylation in Rat Pinealocytes"
  • 6. Schwede F., Maronde E., Genieser H.-G.Jastorff B., Pharmacol. Ther., 87, 199 - 226 (2000), "Cyclic Nucleotide Analogs as Biochemical Tools and Prospective Drugs"