8- Chloroadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Cl-cAMP-AM )
Metabolically activatable prodrug form of 8-Cl-cAMP
Cat. No.: C 050 CAS No.: [pending]
C13H15ClN5O8P; MW 435.7; λmax 262 nm; ε 17000; purity > 97% HPLC for mixture of axial and equatorial isomer. Membrane-permeant precursor of the PKA activator 8-Cl-cAMP (Cat. No. C 007). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. Reference: J. Kruppa, Ph.D. thesis, University of Bremen, Germany, 1996.
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
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