2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate, immobilized on agarose ( 2'-AHC-cGMP-Agarose )
Cyclic GMP immobilized on agarose
The protein kinase G activator cyclic GMP immobilized on agarose by an aminohexylcarbamoyl spacer attached to the ribose 2'- position of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins, especially those which tolerate modification of the 2'- ribose hydroxyl group, such as some phosphodiesterases. References: Kim & Park, J. Biochem. Mol. Biol., 36, 299 - 304 (2003); Scholten et al., J. Proteome Res., 5, 1435 - 1447 (2006). This type of gel is offered as PDE-resistant version (Sp-2'-AHC-cGMPS-Agarose, Cat. No. A 052) as well. Detailed technical information available.
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.
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