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Alternative structural projections:


8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-2'-O-Me-cAMPS ), sodium salt
PDE-resistant, membrane-permeant Epac agonist
Cat. No.: C 052
CAS No.: [634208-37-0]
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Product Name Price (net) Qty
Cat. No.: C 052-01
Unit: 1 µmol / ~0.5 mg
For other salt forms please inquire. Hydrolysis-resistant form of  8-pCPT-2'-O-Me-cAMP (Cat. No. C 041), a specific activator of the exchange protein directly activated by cyclic AMP (Epac) or cAMP-GEF, respectively. The compound does not activate protein kinase A, has high lipophilicity and membrane permeability and is not metabolized by phosphodiesterases. Detailed technical information available. References: Laxman et al., Proc. Natl. Acad. Sci. USA, 103, 19194 - 19199 (2006); Ouyang et al., Proc. Natl. Acad. Sci. USA, 105, 11993 - 11997 (2008).
Cat. No. C 052
Patent Information Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
CAS number [634208-37-0]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₁₆ClN₅O₅PS₂ · Na
Molecular weight [g/mol] 523,9
cAMP modified at the exocyclic oxygen axial (Sp-)
Modifications 8-cAMP, 2'-cAMP
Target Epac Activator
Lipophilicity 3.05
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000