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Alternative structural projections:


Guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-cGMPS ), sodium salt
PDE-resistant PKG inhibitor
Cat. No.: G 016
CAS No.: [86562-09-6]
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Cat. No.: G 016-05
Unit: 5 µmol / ~1.9 mg
For other salt forms please inquire. Inhibitor of protein kinase G Iα. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Caution: Both membrane permeability and kinase specificity of this analogue are low. Rp-8-pCPT-cGMPS (Cat. No. C 013) or Rp-8-Br-PET-cGMPS (Cat. No. P 007) are much more permeant and selective antagonists! In order to avoid disappointments, please use for permeabilized cells or injection techniques only and make sure that lacking cAMP/cGMP specificity is not a problem. Useful of course for in vitro kinase and phosphodiesterase mapping studies! Detailed technical information and updated reference list available on request. Reference: Butt et al., FEBS Lett., 263, 47 - 50 (1990).
Cat. No. G 016
CAS number [86562-09-6]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₁N₅O₆PS · Na
Molecular weight [g/mol] 383,3
Target PKG (cGK) Inhibitor
Lipophilicity 0.89
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300