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pTp

Thymidine- 3', 5'- O- bisphosphate ( pTp ), sodium salt
Cat. No.: T 012
    
CAS No.: [2863-04-9]
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Product Name Price (net) Qty
Cat. No.: T 012-05
Unit: 5 µmol / ~2 mg
$307.00
For other salt forms or analogues please inquire. Accepted by T4 RNA ligase to build oligodeoxyribonucleotides. Competitive inhibitor of staphylococcal nuclease. Detailed technical information available. References: Cuatrecasas et al., J. Biol. Chem., 242, 3063 - 3067 (1967); Hinton et al., Biochemistry , 17, 5091 - 5097 (1978).
Cat. No. T 012
CAS number [2863-04-9]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₆N₂O₁₁P₂
Molecular weight [g/mol] 402,2
Absorption max [nm] 267
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 9600
  • 1. Nandanan E., Camaioni E., Jang S.-Y., Kim Y.-C., Cristalli G., Herdewijin P., Secrist J. A., Tiwari K. N., Mohanram A., Harden T. K., Boyer J. L.Jacobson K. A., J. Med. Chem., 42, 1625 - 1638 (1999), "Structure-Activity Relationships of Bisphosphate Nucleotide Derivatives as P2Y1 Receptor Antagonists and Partial Agonist"
  • 2. Hinton D. M., Baez J. A.Gumport R. I., Biochemistry, 17, 5091 - 5097 (1978), "T4 RNA Ligase Joins 2'-Deoxyribonucleoside 3',5'-bisphosphates to Oligodeoxyribonucleotides"
  • 3. Cuatrecasas P., Fuchs S.Anfinsen C. B., J. Biol. Chem., 242, 3063 - 3067 (1967), "The Binding of Nucleotides and Calcium to the Extracellular Nuclease of Staphylococcus aureus. Studies by Gel Filtration"