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Potential metabolite of the specific Epac activator 8-pCPT-2’-O-Me-cAMP (Cat. No. C 041). The corresponding nucleoside (Cat. No. C 070) and the 5’-monophosphate (Cat. No. C 078) are available as well. Detailed technical information available. Reference: Laxman et al., Proc. Natl. Acad. Sci. USA, 103, 19194 - 19199 (2006).
Cat. No.
C 069
CAS number
[696574-61-5]
Purity
> 95% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₁₁H₈ClN₅S
Molecular weight [g/mol]
277.7
Absorption max [nm]
285
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
16000
1. Enyeart J. A., Liu H.Enyeart J. J., Am. J. Physiol. Endocrinol. Metab., 301, 941 - 954 (2011), "8-Phenylthio-adenines Stimulate the Expression of Steroid Hydroxylases, Cav3.2 Ca2+ Channels, and Cortisol Synthesis by a cAMP-independent Mechanism"
2. Liu H., Enyeart J. J.Enyeart J. A., J. Biol. Chem., 285, 20040 - 20050 (2010), "ACTH Induces CAv3.2. Current and mRNA by cAMP-dependent and cAMP-independent Mechanism"
3. Enyeart J. A.Enyeart J. J., PloS One, 4, 0 - 0 (2009), "Metabolites of an Epac-Selective cAMP Analog Induce Cortisol Synthesis by Adrenocortical Cells through a cAMP-Independent Pathway"
4. Laxman S., Riechers A., Sadilek M., Schwede F.Beavo J. A., PNAS, 103, 19194 - 19199 (2006), "Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-like Forms"