GDP-β-L-fucose (GDP-Fuc) is a nucleotide sugar and the donor substrate for eukaryotic (FUT) and prokaryotic fucosyltransferases (FucT) [1,2]. FUTs and FucTs are utilized for in vitro glycoengineering of biopharmaceutical glycoproteins [3] and cell surface glycans [4]. Further application fields are the synthesis of human milk oligosaccharides [5] and glycan epitopes such as Lewis and blood group antigens [6]. References: [1] Frohnmeyer, H.; Elling, L., Carbohydr. Res., 523, 108727 (2023); [2] Brockhausen I., Front. Immunol., 5, 492 (2014); [3] Jaroentomeechai et al., Nat. Commun., 13, 6325 (2022); [4] Sackstein R., Ann. Biomed. Eng., 40, 766 - 776 (2012); [5] Petschacher, B.; Nidetzky, B., J. Biotechnol., 235, 61 - 83 (2016); [6] Ye, J. et al., 6, 8140-8144 (2016): "Diversity-Oriented Enzymatic Modular Assembly of ABO Histo-blood Group Antigens".
| Cat. No. | G 069 |
| CAS number | [15839-70-0] |
| Purity | guaranteed purity > 95% HPLC, usual purity > 98% |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₆H₂₅N₅O₁₅P₂ (free acid) |
| Molecular weight [g/mol] | 589.3 (free acid) |
| Absorption max [nm] | 253 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 13500 |
| UV pH value | 7 |
| Solvent for UV data | Water |
