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Alternative structural projections:

MANT-cGMP

2'- O- (N'- Methylanthraniloyl)guanosine- 3', 5'- cyclic monophosphate, sodium salt ( MANT-cGMP )
Fluorescent, PKG-inactive cyclic GMP analogue
Cat. No.: M 009
    
CAS No.: [83707-15-7]
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Product Name Price (net) Qty
Cat. No.: M 009-10
Unit: 10 µmol / ~5 mg
$186.00
For other salt forms, metabolites or anthraniloyl- cGMP please inquire. Fluorescent cyclic GMP analogue ( λexc 350 nm, λem 441 nm), suitable for phosphodiesterase studies. The compound shows a decrease in fluorescence when cleaved by PDE. Detailed technical information available. References: Hiratsuka, J. Biol. Chem., 257, 13354 - 13358 (1982); Johnson, Anal. Biochem., 162, 291 - 295 (1987); Brown et al., Biochem. Biophys. Res. Commun., 224, 684 - 689 (1996).
Cat. No. M 009
CAS number [83707-15-7]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₈H₁₈N₆O₈P · Na
Molecular weight [g/mol] 500,3
Modifications 2'-cGMP
Excitation max [nm] 350
Emission max [nm] 441
Lipophilicity 2.00
Absorption max [nm] 252/350
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 21500/ 5300
UV pH value 8
  • 1. Wang J. L., Guo J.-X., Zhang Q.-Y., Wu J. J.-Q., Seifert R.Lushington G. H., Bioorg. Med. Chem., 15, 2993 - 3002 (2007), "A Conformational Transition in the Adenylyl Cyclase Catalytic Site Yields Different Binding Modes for Ribosyl-modified and Unmodified Nucleotide Inhibitors"
  • 2. Mou T.-C., Gille A., Fancy D. A., Seifert R.Sprang S. R., J. Biol. Chem., 280, 7253 - 7261 (2005), "Structural Basis for the Inhibition of Mammalian Membrane Adenylyl Cyclase by 2'(3')-O-(N-Methylanthraniloyl)-guanosine 5'-triphosphate"
  • 3. Brown J. E.Kelman E. S., Biochem. Biophys. Res. Commun., 224, 684 - 689 (1996), "Ca2+ Induces an Increase in cGMP-Phosphodiesterase Activity in Squid Retinal Photoreceptors"
  • 4. Johnson J. D., Walters J. D.Mills J. S., Anal. Biochem., 162, 291 - 295 (1987), "A Continous Fluorescence Assay for Cyclic Nucleotide Phosphodiesterase Hydrolysis of Cyclic GMP"
  • 5. Hiratsuka T., J. Biol. Chem., 257, 13354 - 13358 (1982), "New Fluorescent Analogs of cAMP and cGMP Available as Substrates for Cyclic Nucleotide Phosphodiesterase"