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  1. Modifications: 8-cGMP
  2. Target: PKG (cGK) Inhibitor
cGMP modified at the exocyclic oxygen
  1. equatorial (Rp-) (4)
Lipophilicity

Lipophilicity ranking is based on log kw data. To be membrane-permeant, analogues should have a log kw of at least 1.2
See also: Lipophilic Ranking of Cyclic Nucleotide Analogs

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PDE- resistant PKG Inhibitors

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